Benzoyl chloride → HCID 12565366, compound
Reaction equation
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:11][CH2:12][P:13]([CH2:16][NH2:17])(=[O:15])[OH:14]>N1C=CC=CC=1>[C:1]([NH:11][CH2:12][P:13]([CH2:16][NH:17][C:1](=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)(=[O:14])[OH:15])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
Benzoyl chloride (1.8 ml; 15.49 mmol) is added slowly with stirring at 0° C. to a solution of bis(aminomethyl)phosphinic acid hydrochloride (1.20 g; 7.48 mmol) in pyridine (8 ml). The reaction mixture is concentrated under reduced pressure. The residue is taken up in 5% hydrochloric acid (60 ml). The aqueous phase is extracted with ethyl acetate (3×60 ml). The combined organic phases are dried (sodium sulfate) and concentrated under reduced pressure. The phosphinic acid 2 (1.95 g) is obtained as a crude product.