8-Azido-1-octanol → 8-Amino-1-octanol
Reaction equation
[N:1]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12])=[N+]=[N-]>C(O)C.[Pd].CC([O-])=O.CC([O-])=O.[Pb+2]>[NH2:1][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12]Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
8-Azido-octan-1-ol (1.99 g, 11.6 mmol) was dissolved in ethanol (25 mL) and Lindlar catalyst (200 mg) was added. The solution was hydrogenated at 50 psi, 30° C. for 2 hours. The catalyst was removed by filtration through Kieselguhr and the solvent was removed in vacuo to give a white solid 1.33 g (79% yield), mp 48°-53° C.;
Workup
- customThe catalyst was removed by filtration through Kieselguhr
- customthe solvent was removed in vacuo
Sources & evidence
- ORD record
- ord-fd8c1ef75d4b4d6ba5b5d39f72ac4ac1
- Source dataset
- uspto-grants-1997_03
- Patent number
- US05610145
Reaction notes
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