p-Pentoxybenzoyl chloride → 10, 11-Dihydro-10(4-(5-pentyloxy)benzoyl)-5H-pyrrolo[2,1-c][1, 4]benzodiazepine

HRID 976432Notes

Reaction equation

HRID 976432 reaction equation
[CH2:1]([O:6][C:7]1[CH:15]=[CH:14][C:10]([C:11](Cl)=[O:12])=[CH:9][CH:8]=1)[CH2:2][CH2:3][CH2:4][CH3:5].[CH:16]1[CH:17]=[CH:18][N:19]2[CH2:25][C:24]3[CH:26]=[CH:27][CH:28]=[CH:29][C:23]=3[NH:22][CH2:21][C:20]=12>>[CH3:5][CH2:4][CH2:3][CH2:2][CH2:1][O:6][C:7]1[CH:15]=[CH:14][C:10]([C:11]([N:22]2[C:23]3[CH:29]=[CH:28][CH:27]=[CH:26][C:24]=3[CH2:25][N:19]3[CH:18]=[CH:17][CH:16]=[C:20]3[CH2:21]2)=[O:12])=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 94910p-Pentoxybenzoyl chlorideHCID 1554704810,11-Dihydro-5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine

Product 1

HCID 1891749810, 11-Dihydro-10(4-(5-pentyloxy)benzoyl)-5H-pyrrolo[2,1-c][1, 4]benzodiazepine

Procedure

As described for Example 343 4-(n-pentyloxy)benzoyl chloride is reacted with 10,11-dihydro-5H-pyrrolo[2,1-c][1,4]benzodiazepine to the desired product as a solid:mass spectrum(CI),375(MH+).

Sources & evidence

ORD record
ord-aec3531beebb49c4a8a4eeb7a724b5af
Source dataset
uspto-grants-1997_03
Patent number
US05612334

Reaction notes

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