HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Hydroxylamine HCl | HCID 21645 | — |
| Reactant | 3-(4-Cyanophenyl)-2-oxo-5-oxazolidinecarboxylic acid | HCID 15340939 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | 3-[4-(Amino(hydroxylimino)methyl)phenyl]-2-oxo-5-oxazolidinecarboxylic acid, hydrochloride | HCID 131719938 | — |
Reaction Steps
27.9 g of 3-(4-cyanophenyl)-2-oxo-5-oxazolidine carboxylic acid [obtainable according to Example 1] and 26.4 g of hydroxylammonium chloride are boiled for 5 h in a mixture of 750 ml of methanol and 30 ml of water in the presence of 53.4 g of sodium carbonate. The precipitate formed is filtered off with suction, washed with methanol and dried. Treatment with hydrochloric acid gives 3-[4-(amino(hydroxylimino)methyl)phenyl]-2-oxo-5-oxazolidinecarboxylic acid, hydrochloride, m.p. 205°-208°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05614535 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-ebafdefec83f481baf0af317c189a8f8 |
| Source note | uspto-grants-1997_03 |