HuagongsheHuagongshe Chemistry Print Report · For research reference only
Azepane-2,4-dione → 4-Methoxyazepan-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Azepane-2,4-dione | HCID 20204020 | — |
| Reactant | Methylorthoformate | HCID 53629101 | — |
| Catalyst | p-Toluenesulfonic acid | HCID 6101 | — |
| Product | 4-Methoxyazepan-2-one | HCID 19043822 | 63.8% |
Reaction Steps
2,4-Dioxohexahydroazepine (4.57 g), methyl orthoformate (8.15 g) and p-toluenesulfonic acid (215 mg) are treated in the same manner as described in Example 1-(1) to give 4-methoxy-2,4,6,7-tetrahydroazepine-2-one (3.24 g, 63.8%) as colorless prisms. m.p. 70°-73° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04663319 |
| Source dataset | uspto-grants-1987_05 |
| ORD ID | ord-8c9355e9166245eca042c98c42a6e8d5 |
| Source note | uspto-grants-1987_05 |