Glycine → N-Heptanoylglycine
Reaction equation
[NH2:1][CH2:2][C:3]([OH:5])=[O:4].[C:6](Cl)(=[O:13])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[OH-].[Na+]>O.CCOCC>[C:6]([NH:1][CH2:2][C:3]([OH:5])=[O:4])(=[O:13])[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]Participants
6
Reactant 3
Product 1
Reagents, catalysts & solvents 2
Procedure
Glycine (1.5 g, 20 mmol) and heptanoyl chloride (22 mmol) were reacted in the presence of NaOH (40 mmol) in a mixture of water and ether using the method described in Example 5. The crude product was recrystallized from EtOAc (30 ml) to give title compound (2.71 g, 72%), m.p. 98°-100° C.
Workup
- customThe crude product was recrystallized from EtOAc (30 ml)
Sources & evidence
- ORD record
- ord-9bd0469804594399bc8f87474c3d7956
- Source dataset
- uspto-grants-1987_05
- Patent number
- US04663336
Reaction notes
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