HCID 14075472, compound → N,N-Diethyl-3-pyrrolidinemethanamine

HRID 978595

Reaction equation

HRID 978595 reaction equation
[CH2:1]([N:3]([CH2:17][CH3:18])[CH2:4][CH:5]1[CH2:9][CH2:8][N:7](CC2C=CC=CC=2)[CH2:6]1)[CH3:2].[H][H]>[Pd].CO>[CH2:17]([N:3]([CH2:1][CH3:2])[CH2:4][CH:5]1[CH2:9][CH2:8][NH:7][CH2:6]1)[CH3:18]

Participants

5

Reactant 2

HCID 14075472HCID 14075472, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 14075474N,N-Diethyl-3-pyrrolidinemethanamineYield 101.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 25.4 g (0.10 mole) of N,N-diethyl-1-(phenylmethyl)-3-pyrrolidinemethanamine, 200 ml of methyl alcohol, 2 g of palladium on carbon and hydrogen were shaken at a pressure of 51.5 psi. After 20.3 hours, the catalyst was filtered and the filtrate concentrated under reduced pressure. The residue was bulb to bulb distilled giving 15.9 g of N,N-diethyl-3-pyrrolidinemethanamine.

Workup

  1. filtrationthe catalyst was filtered
  2. concentrationthe filtrate concentrated under reduced pressure
  3. distillationdistilled

Sources & evidence

ORD record
ord-e7febe3b43c34959b96b8427691a395a
Source dataset
uspto-grants-1987_05
Patent number
US04665079

Linked notes

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