Folic Acid → Tetrahydrofolic acid

Participants

Reaction Steps

Then, a suspension of 0.230 g of a 5% rhodium-activated carbon catalyst (containing the noble metal in an amount of 0.55% by weight based on the folic acid) in 25 ml of distilled water was added to the flask, and hydrogenation was carried out in the same manner as described in Example 1 to obtain 1.593 g (75.3% yield) of tetrahydrofolic acid.

Provenance & Evidence