HCID 20201103, compound → 4-Methyl-2-(methylthio)thiophen-3-amine
Reaction equation
[CH3:1][S:2][C:3]1[S:4][CH:5]=[C:6]([CH3:11])[C:7]=1[N+:8]([O-])=O>C(OCC)C>[CH3:1][S:2][C:3]1[S:4][CH:5]=[C:6]([CH3:11])[C:7]=1[NH2:8]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
6 g (0.22 gram atoms) freshly prepared aluminium amalgam are added over a period of about two minutes to 18.9 g (0.1 mol) of 2-methylthio-4-methyl-3-nitrothiophene dissolved in 200 ml of moist diethylether. The vigorous reaction which sets in after 5-10 minutes is kept under control by cooling the flask in ice.
Workup
- customThe vigorous reaction which
- customafter 5-10 minutes
- temperatureby cooling the flask in ice
Sources & evidence
- ORD record
- ord-dfa6b5a73c394992a319395e4b4c1656
- Source dataset
- uspto-grants-1987_05
- Patent number
- US04666502
Reaction notes
Loading…