Sodium Methoxide → 1-(4-Aminocyclohexyl)-3-ethylurea
Reaction equation
Cl.[NH2:2][CH:3]1[CH2:8][CH2:7][CH:6]([NH:9][C:10]([NH:12][CH2:13][CH3:14])=[O:11])[CH2:5][CH2:4]1.C[O-].[Na+]>CO>[NH2:2][CH:3]1[CH2:8][CH2:7][CH:6]([NH:9][C:10]([NH:12][CH2:13][CH3:14])=[O:11])[CH2:5][CH2:4]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 1.5 g of 1-(4-aminocyclohexyl)-3-ethylurea hydrochloride in 20 ml of methyl alcohol is treated with 0.36 g of sodium methoxide, to yield after usual workup 1-(4-aminocyclohexyl)-3-ethylurea as an oil which is used directly in the above condensation.
Sources & evidence
- ORD record
- ord-7d56d3b0490c46be9553e42cbfec1836
- Source dataset
- uspto-grants-1987_01
- Patent number
- US04634713
Reaction notes
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