Acetic Acid → tert-butyl N-[4-(2-fluoroethyl)piperidin-3-yl]carbamate

Reaction equation

[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]([NH:17][C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH:11]([CH2:14][CH2:15][F:16])[CH2:12][CH2:13]1.[CH3:25][OH:26].[CH3:27][C:28](=[O:29])[OH:30].[OH-:31].[OH-:33].[Pd+2:32]>>[NH:8]1[CH2:9][CH:10]([NH:17][C:18](=[O:19])[O:20][C:21]([CH3:22])([CH3:23])[CH3:24])[CH:11]([CH2:14][CH2:15][F:16])[CH2:12][CH2:13]1

Participants

Reactant 5

HCID 176Acetic Acid

HCID 887Methanol

HCID 961Hydroxide2×

HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

HCID 18771301HCID 18771301, compound

Product 1

HCID 18771302tert-butyl N-[4-(2-fluoroethyl)piperidin-3-yl]carbamate

Sources & evidence

ORD record: ord-572ecc456f8b4e0191962be601165812
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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