2-bromo-N-(2,6-dimethylphenyl)acetamide → N-(2,6-dimethylphenyl)-4-(4-phenoxyphenyl)-1-piperidinacetamide
Reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][C:10](=[O:13])[CH2:11]Br.[O:14]([C:21]1[CH:26]=[CH:25][C:24]([CH:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)=[CH:23][CH:22]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][C:10](=[O:13])[CH2:11][N:30]1[CH2:31][CH2:32][CH:27]([C:24]2[CH:25]=[CH:26][C:21]([O:14][C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:22][CH:23]=2)[CH2:28][CH2:29]1Participants
3
Procedure
The compound (18) synthesized in Reference Example 18 and the compound (4) synthesized in Reference Example 4 were used to produce the above compound in the same way as Example 1.
Workup
- customto produce the above compound in the same way as Example 1
Sources & evidence
- ORD record
- ord-42b70ec5c4314890af50156b46d84803