Propanal → 1-(2,3,5-Trimethyl-6-pyrazinyl)-1-propanone

HRID 980075

Reaction equation

[CH3:1][C:2]1[N:3]=[C:4]([CH3:9])[C:5]([CH3:8])=[N:6]C=1.[CH:10](=O)CC.[CH3:14][C:15]([CH3:17])=[O:16].CCCCCC>>[CH3:8][C:5]1[C:4]([CH3:9])=[N:3][C:2]([CH3:1])=[C:14]([C:15](=[O:16])[CH2:17][CH3:10])[N:6]=1

Participants

Reactant 3

HCID 527Propanal

HCID 26808Trimethylpyrazine

HCID 21880519Acetone hexane

Product 1

HCID 5779401-(2,3,5-Trimethyl-6-pyrazinyl)-1-propanoneYield 48%

Procedure

The reaction of trimethylpyrazine and freshly distilled propionaldehyde is carried out as described in Example I on the same molar scale. Preparative thick layer chromatography (2000μ silica gel GF, developed in 5% acetone/hexane) of the crude reaction product gives a 48% yield of 1-(2,3,5-trimethyl-6-pyrazinyl)-1-propanone (mp 65°-67° C.).

Sources & evidence

ORD record: ord-5db9e4108e4e47afb11712a9b0b1966b
Source dataset: uspto-grants-1987_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04635652

Linked notes

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