Reaction equation
N1C=CN=CC=1[CH:7](C)[C:8]([OH:10])=[O:9].[CH3:12][C:13]1[CH:18]=[N:17][CH:16]=[CH:15][N:14]=1.ClC(Cl)(Cl)C=O.[OH-]>>[N:14]1[CH:15]=[CH:16][N:17]=[CH:18][C:13]=1[CH:12]=[CH:7][C:8]([OH:10])=[O:9]Participants
5
Procedure
Scheme M depicts a specific synthesis of a pyrazinyl propionic acid. Methylpyrazine anion is condensed with trichloroacetaldehyde followed by treatment with base (hydroxide), then acidification to produce 3-(-Pyrazinyl) Acrylic Acid 75. This acid is then catalytically hydrogenated over palladium on charcoal to yield 3-(2-Pyrazinyl)propionic Acid 76.
Sources & evidence
- ORD record
- ord-c13ea9ac38ac4cf591514329645f7d16
- Source dataset
- uspto-grants-1987_01
- Patent number
- US04638005
Linked notes
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