Ethyl chloroformate → N-(1,1-dimethoxyprop-2-yl)urethane

Participants

Reaction Steps

80 g (0.73 mol) of ethyl chloroformate are added dropwise to 86.2 g (0.72 mol) of 2-aminopropionaldehyde dimethyl acetal in 350 ml of toluene and 32 g (0.8 mol) of NaOH in 300 ml of water. The mixture is stirred at room temperature for a further 2 hours, the organic phase is separated off, the aqueous phase is extracted with toluene and the toluene solutions are dried over K CO2. The solution is concentrated and the residue is distilled.

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