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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 983339Generated: October 25, 2026

methyl L-prolinate hydrochloride → N-(N-(Phenylacetyl)-L-alaninyl]-L-proline Methyl Ester

https://huagongshe.com/reaction/983339

Reaction equation

Participants

RoleNameHCIDCharge
Reactantmethyl L-prolinate hydrochlorideHCID 2733200—
ReactantN-(Phenylacetyl)-L-alanineHCID 7004640—
ProductN-(N-(Phenylacetyl)-L-alaninyl]-L-proline Methyl EsterHCID 22895052—

Reaction Steps

Following General Procedure A and using N-(phenylacetyl)-L-alanine (from Example B1 above) and L-proline methyl ester hydrochloride (Bachem), the title compound was prepared as an oil. The reaction was monitored by tlc (Rf=0.12 in 50% EtOAc/hexanes).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06861558B2
Source datasetuspto-grants-2005_03
ORD IDord-681796697e5748e4aad9c714c1163891
Source noteuspto-grants-2005_03