2,4-Dichlorobenzylidenemalononitrile → 5-Aminomethyl-6-(2,4-dichloro-phenyl)-2-(3,4-dimethoxy-phenyl)-pyrimidin-4-ylamine

HRID 983847

Reaction equation

HRID 983847 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[O:12][CH3:13])[C:6]([NH2:8])=[NH:7].[Cl:14][C:15]1[CH:26]=[C:25]([Cl:27])[CH:24]=[CH:23][C:16]=1[CH:17]=[C:18]([C:21]#[N:22])[C:19]#[N:20]>>[NH2:22][CH2:21][C:18]1[C:19]([NH2:20])=[N:7][C:6]([C:5]2[CH:9]=[CH:10][C:11]([O:12][CH3:13])=[C:3]([O:2][CH3:1])[CH:4]=2)=[N:8][C:17]=1[C:16]1[CH:23]=[CH:24][C:25]([Cl:27])=[CH:26][C:15]=1[Cl:14]

Participants

3

Reactant 2

HCID 180892,4-DichlorobenzylidenemalononitrileHCID 40034Benzenecarboximidamide, 3,4-dimethoxy-

Product 1

HCID 102377565-Aminomethyl-6-(2,4-dichloro-phenyl)-2-(3,4-dimethoxy-phenyl)-pyrimidin-4-ylamine

Procedure

The title compound, MS: m/e=405.3 (M+H+), was prepared from 3,4-dimethoxy-benzamidine and 2-(2,4-dichloro-benzylidene)-malononitrile in analogy to the process described in Example 11 as a solid.

Sources & evidence

ORD record
ord-7f346a3f80ff4d079d22bdfab96c7dda
Source dataset
uspto-grants-2005_03
Patent number
US06867205B2

Linked notes

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