Iodine → 6-(1-fluoroethyl)-5-iodo-4-pyrimidone
Reaction equation
[F:1][CH:2]([C:4]1[N:9]=[CH:8][NH:7][C:6](=[O:10])[CH:5]=1)[CH3:3].[I:11]Cl.II.ClCl>C(O)(=O)C>[F:1][CH:2]([C:4]1[N:9]=[CH:8][NH:7][C:6](=[O:10])[C:5]=1[I:11])[CH3:3]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
To an acetic acid (150 ml) solution of 6-(1fluoroethyl)-4-pyrimidone (56.8 g) was added dropwise under room temperature and stirring an acetic acid solution of iodine monochloride prepared by adding iodine (50.8 g) to acetic acid (500 ml) and blowing chlorine (15 g) thereinto under room temperature and stirring, and the resulting mixture was stirred for 6 hours.
Workup
- customprepared
- stirringthe resulting mixture was stirred for 6 hours
Sources & evidence
- ORD record
- ord-4abd0c6191b643289218bc490ab01772
- Source dataset
- uspto-grants-2005_03
- Patent number
- US06867212B2
Reaction notes
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