4-Piperidinecarboxamide → HCID 22558065, compound

Reaction equation

[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]([NH2:9])=[O:8])[CH2:3][CH2:2]1.[Cl:10][C:11]1[C:16]([O:17][CH3:18])=[CH:15][C:14]([C:19]2[CH:24]=[C:23]([CH2:25]Cl)[CH:22]=[CH:21][N:20]=2)=[CH:13][C:12]=1[O:27][CH3:28]>>[Cl:10][C:11]1[C:16]([O:17][CH3:18])=[CH:15][C:14]([C:19]2[CH:24]=[C:23]([CH2:25][N:1]3[CH2:6][CH2:5][CH:4]([C:7]([NH2:9])=[O:8])[CH2:3][CH2:2]3)[CH:22]=[CH:21][N:20]=2)=[CH:13][C:12]=1[O:27][CH3:28]

Participants

Reactant 2

HCID 37724-Piperidinecarboxamide

HCID 22557787HCID 22557787, compound

Product 1

HCID 22558065HCID 22558065, compound

Procedure

Piperidine-4-carboxamide (301 mg) and 2-(4-chloro-3,5-dimethoxyphenyl)-4-chloromethylpyridine (600 mg) were coupled in the same manner as described in Example 2 to give the title compound.

Sources & evidence

ORD record: ord-2375ffb784914e44906b0a93ede05eeb
Source dataset: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06867221B2

Reaction notes

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