4-Chloroaniline → Tert-butyl 4-(4-chlorophenylamino)piperidine-1-carboxylate

HRID 984281

Reaction equation

HRID 984281 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:15][C:16]1[CH:22]=[CH:21][C:19]([NH2:20])=[CH:18][CH:17]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:20][C:19]2[CH:21]=[CH:22][C:16]([Cl:15])=[CH:17][CH:18]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 78124-ChloroanilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 1491503Tert-butyl 4-(4-chlorophenylamino)piperidine-1-carboxylate

Procedure

1-(tert-Butoxycarbonyl)-4-piperidone (5.00 g) and 4-chloroaniline (3.05 g) was treated in the same manner as described in Preparation Example 37 to give white powder of the title compound.

Workup

  1. customas described in Preparation Example 37

Sources & evidence

ORD record
ord-f94b60ea74bb454684dced03a68c0298
Source dataset
uspto-grants-2005_03
Patent number
US06867221B2

Linked notes

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