3,4-Difluoroaniline → 1-Boc-4-[(3,4-difluorophenyl)amino]-piperidine

HRID 984284

Reaction equation

HRID 984284 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[F:15][C:16]1[CH:17]=[C:18]([CH:20]=[CH:21][C:22]=1[F:23])[NH2:19]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([NH:19][C:18]2[CH:20]=[CH:21][C:22]([F:23])=[C:16]([F:15])[CH:17]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 774693,4-DifluoroanilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 225580331-Boc-4-[(3,4-difluorophenyl)amino]-piperidine

Procedure

1-(tert-Butoxycarbonyl)-4-piperidone (5.00 g) and 3,4-difluoroaniline (3.09 g) was treated in the same manner as described in Preparation Example 37 to give light brown prism crystal of the title compound.

Workup

  1. customas described in Preparation Example 37

Sources & evidence

ORD record
ord-b6ca679ff84e45fe9b0b66d52c225eee
Source dataset
uspto-grants-2005_03
Patent number
US06867221B2

Linked notes

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