Methanesulfonamide → HCID 178431435, compound

Reaction equation

[CH3:1][C:2]1[C:3]([O:18][CH2:19][CH2:20][CH2:21][NH:22][S:23]([CH3:26])(=[O:25])=[O:24])=[CH:4][N:5]2[C:10]=1[C:9]([O:11]C1C=CC=CC=1)=[N:8][CH:7]=[N:6]2.CS(N)(=O)=O>>[OH:11][C:9]1[C:10]2=[C:2]([CH3:1])[C:3]([O:18][CH2:19][CH2:20][CH2:21][NH:22][S:23]([CH3:26])(=[O:25])=[O:24])=[CH:4][N:5]2[N:6]=[CH:7][N:8]=1

Participants

Reactant 2

HCID 72879Methanesulfonamide

HCID 22508873N-[3-(5-methyl-4-phenoxy-pyrrolo[2,1-f][1,2,4]triazin-6-yloxy)-propyl]-methanesulfonamide

Product 1

HCID 178431435HCID 178431435, compoundYield 64%

Procedure

The compound from Step A above was treated with methanesulfonamide by a procedure similar to that described for the preparation of Example 24 to obtain N-[3-(4-hydroxy-5-methyl-pyrrolo[2,1-f][1,2,4]triazin-6yloxy)-propyl]-methanesulfonamide. (64% yield). MS: (M+H)+=301.

Workup

customthat described for the preparation of Example 24

Sources & evidence

ORD record: ord-b3cb394140de45839eeb832ff07c2325
Source dataset: uspto-grants-2005_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06869952B2

Reaction notes

Loading…