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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 985021Generated: October 25, 2026

1-Chloro-4-(chloromethyl)benzene → 2-(4-chlorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one

https://huagongshe.com/reaction/985021

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Chloro-4-(chloromethyl)benzeneHCID 7723—
Reactant6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-oneHCID 21991432—
Product2-(4-chlorobenzyl)-6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-oneHCID 2199151197.6%

Reaction Steps

Following the procedure of Example 1(6), 6-(3-fluoro-4-methoxyphenyl)-4-methoxycarbonyl-2H-pyridazin-3-one and 4-chlorobenzyl chloride were reacted to yield the title compound as yellow needles (yield: 97.6%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06869954B2
Source datasetuspto-grants-2005_03
ORD IDord-802857f5a12947d69dfc561e5ce2a07e
Source noteuspto-grants-2005_03