HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexamethylphosphoramide → Bifonazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexamethylphosphoramide | HCID 12679 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | HCID 178419618 | HCID 178419618 | — |
| Product | Bifonazole | HCID 2378 | 68.2% |
Reaction Steps
Bifonazole has also been prepared by benzoylation of imidazole with PhCOCl, yielding 74.7% of 1-benzoylimidazole which is subject to react with Gringnard's reactant 4-PhC6H4MgBr followed by a tosylation and subsequent reduction with sodium cyanoborohydride in hexamethylphosphoramide, to yield 68.2% Bifonazole (Es. Patent 539,345).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06870057B1 |
| Source dataset | uspto-grants-2005_03 |
| ORD ID | ord-30e3f2394175491b9a9d832f7048cedb |
| Source note | uspto-grants-2005_03 |