Nitric Acid → 1-Chloro-4,5-dimethoxy-2-nitrobenzene

HRID 986631

Reaction equation

HRID 986631 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([Cl:11])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[N+:12]([O-])([OH:14])=[O:13]>>[CH3:10][O:9][C:8]1[C:3]([O:2][CH3:1])=[CH:4][C:5]([Cl:11])=[C:6]([N+:12]([O-:14])=[O:13])[CH:7]=1

Participants

3

Reactant 2

HCID 944Nitric AcidHCID 280484-Chloro-1,2-dimethoxybenzene

Product 1

HCID 123212731-Chloro-4,5-dimethoxy-2-nitrobenzene

Procedure

Into a triple-necked flask of one liter, provided with a magnetic stirring system, with a thermometer and a dropping funnel, were introduced successively 143.9 g (0.83 mole) of 3,4-dimethoxy chlorobenzene, then drop by drop 166 cm3 of nitric acid (d=1.38), without the temperature exceeding 25° C. When the addition was ended, the reaction mixture was allowed to stand 1.5 h and then filtered.

Workup

  1. customInto a triple-necked flask of one liter, provided with a magnetic stirring system, with a thermometer and a dropping funnel
  2. customexceeding 25° C
  3. additionWhen the addition
  4. filtrationfiltered

Sources & evidence

ORD record
ord-8acf310d23614ea8b5fbe61885e9c4f2
Source dataset
uspto-grants-1987_12
Patent number
US04714700

Linked notes

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