Sodium Hydroxide → 7-Thienylamino-1H-pyrazolo[4,3-b]pyridine

HRID 986746

Reaction equation

HRID 986746 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[NH:6][C:7]1[C:12](C(OCC)=O)=[CH:11][N:10]=[C:9]2[CH:18]=[N:19][NH:20][C:8]=12.[OH-].[Na+]>C(O)C>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[NH:6][C:7]1[CH:12]=[CH:11][N:10]=[C:9]2[CH:18]=[N:19][NH:20][C:8]=12

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20156241Ethyl 7-thienylamino-1H-pyrazolo[4,3-b]pyridine-6-carboxylate

Product 1

HCID 201562447-Thienylamino-1H-pyrazolo[4,3-b]pyridine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 7-thienylamino-1H-pyrazolo[4,3-b]pyridine-6-carboxylate (0.600 g) was converted to the corresponding acid by heating under reflux with a 2% sodium hydroxide solution in ethanol (50 ml). The ethanol was removed under reduced pressure and the residue diluted with water (5 ml) and acidified to pH5 with dilute hydrochloric acid. The resulting acid was filtered off and dried, mp 255°-259° C.

Workup

  1. temperatureby heating
  2. customThe ethanol was removed under reduced pressure
  3. additionthe residue diluted with water (5 ml)
  4. filtrationThe resulting acid was filtered off
  5. customdried

Sources & evidence

ORD record
ord-795da91dd8ec4d3bba0d28a4380803d5
Source dataset
uspto-grants-1987_12
Patent number
US04716160

Linked notes

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