2-Thiopheneboronic acid → 1-Benzhydryl-5-(2-thienyl)-1H-indole-2-carboxylic Acid

HRID 987166

Reaction equation

HRID 987166 reaction equation
[CH:1]([N:14]1[C:22]2[C:17](=[CH:18][C:19](Br)=[CH:20][CH:21]=2)[CH:16]=[C:15]1[C:24]([OH:26])=[O:25])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[S:27]1[CH:31]=[CH:30][CH:29]=[C:28]1B(O)O>>[CH:1]([N:14]1[C:22]2[C:17](=[CH:18][C:19]([C:28]3[S:27][CH:31]=[CH:30][CH:29]=3)=[CH:20][CH:21]=2)[CH:16]=[C:15]1[C:24]([OH:26])=[O:25])([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27339602-Thiopheneboronic acidHCID 229882391-Benzhydryl-5-bromo-1H-indole-2-carboxylic Acid

Product 1

HCID 229882181-Benzhydryl-5-(2-thienyl)-1H-indole-2-carboxylic Acid

Procedure

The title compound was prepared according to the procedure described in Example 109 except that 1-benzhydryl-5-bromo-1H-indole-2-carboxylic acid and 2-thiopheneboronic acid were used.

Sources & evidence

ORD record
ord-da33c6b9179c41dbb7aac667ccb7412e
Source dataset
uspto-grants-2003_10
Patent number
US06630496B1

Linked notes

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