Methyl Carbamate → HCID 23498176, compound

Temperature

140 °C

A mixture containing 50 g (0.67 mole) of methyl carbamate, 272 g (3.20 moles) of pyrrolidone, 2.4 g of TK-1 tin catalyst, and 2.4 g of DAMA-10 was heated at 140° C. under 40-50 mm Hg pressure for 3.5 hours. The methanol produced by the reaction was collected in a dry ice-acetone trap during the reaction. The reaction mixture was then analyzed with GLC (internal standard method). The results indicated that the yield of pyrrolidone urea was 85% based on methyl carbamate charged, and 10% of the starting methyl carbamate still remained in the reaction mixture. The reaction mixture was then distilled under reduced pressure to remove excess pyrrolidone and the remaining methyl carbamate. The residue was stirred with 200 ml of toluene for 15 minutes and filtered. The collected solid was washed with toluene and air-dried to afford 46 g (54%) of the desired product; mp 142°-144° C. (lit. mp 142°-143° C.); IR (cm−1): 3360, 1710, 1660, 1590, 1370, 1250; 1H-NMR (CDCl3): δ8.2 (s, 1 H), 5.9 (s, 1 H), 3.9 (t, 2 H), 2.6 (t, 2 H), 2.1 (t, 2 H).

1. customwas collected in a dry ice-acetone trap during the reaction
2. additioncharged
3. distillationThe reaction mixture was then distilled under reduced pressure
4. customto remove excess pyrrolidone
5. filtrationfiltered
6. washThe collected solid was washed with toluene
7. customair-dried

ORD record

ord-82a70b275eae4ff3a08aca97c63c859d

Source dataset

uspto-grants-2003_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06630599B1