2-Bromo-N-phenylacetamide → N-phenyl-4-[4-(4-fluorophenyl)methylphenyl]-1-piperidinacetamide

HRID 989

Reaction equation

HRID 989 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([CH:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)=[CH:11][CH:10]=2)=[CH:4][CH:3]=1.[C:21]1([NH:27][C:28](=[O:31])[CH2:29]Br)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[C:21]1([NH:27][C:28](=[O:31])[CH2:29][N:18]2[CH2:17][CH2:16][CH:15]([C:12]3[CH:13]=[CH:14][C:9]([CH2:8][C:5]4[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=4)=[CH:10][CH:11]=3)[CH2:20][CH2:19]2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 948182-Bromo-N-phenylacetamideHCID 154621204-[4-(4-Fluorophenyl)methylphenyl]piperidine

Product 1

HCID 19694263N-phenyl-4-[4-(4-fluorophenyl)methylphenyl]-1-piperidinacetamide

Procedure

The compound (7) synthesized in Reference Example 7 and the compound (23) synthesized in Reference Example 23 were used to produce the above compound in the same way as Example 1.

Workup

  1. customto produce the above compound in the same way as Example 1

Sources & evidence

ORD record
ord-0dbe0dca9fae46829877e914cdfc371e
Source dataset
uspto-grants-1998_03
Patent number
US05723475

Linked notes

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