(S)-1-Benzyl 2-methyl 4-methylenepyrrolidine-1,2-dicarboxylate → HCID 45089984, compound

(S)-1-Benzyloxycarbonyl-4-methylideneproline methyl ester (1.80 g (6.5 mmol), prepared as described in 1)) was dissolved in methanol (50 ml). The resulting solution was stirred at room temperature in an atmosphere of hydrogen in the presence of 10% palladium on charcoal (180 mg) for 2 hours. At the end of this time, the reaction mixture was filtered to remove the catalyst and the filtrate was concentrated by evaporation under reduced pressure, to give the title compound (0.93 g) as a pale yellow oil (yield quantitative).

1. filtrationAt the end of this time, the reaction mixture was filtered
2. customto remove the catalyst
3. concentrationthe filtrate was concentrated by evaporation under reduced pressure

ORD record

ord-f51ae708c7b34b70880763ac6b68d07a

Source dataset

uspto-grants-2006_08

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07091352B2