4-(4-Phenoxyphenyl)piperidine → N-(2,6-diisopropylphenyl)-4-(4-phenoxyphenyl)-1-piperidinacetamide

HRID 990

Reaction equation

HRID 990 reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:20]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH:29]([CH3:31])[CH3:30])[C:24]=1[NH:32][C:33](=[O:36])[CH2:34]Br)([CH3:22])[CH3:21]>>[CH:20]([C:23]1[CH:28]=[CH:27][CH:26]=[C:25]([CH:29]([CH3:30])[CH3:31])[C:24]=1[NH:32][C:33](=[O:36])[CH2:34][N:17]1[CH2:18][CH2:19][CH:14]([C:11]2[CH:12]=[CH:13][C:8]([O:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[CH:9][CH:10]=2)[CH2:15][CH2:16]1)([CH3:21])[CH3:22]

Participants

3

Reactant 2

HCID 110759844-(4-Phenoxyphenyl)piperidineHCID 12149064Acetamide, N-[2,6-bis(1-methylethyl)phenyl]-2-bromo-

Product 1

HCID 19694264N-(2,6-diisopropylphenyl)-4-(4-phenoxyphenyl)-1-piperidinacetamide

Procedure

The compound (4) synthesized in Reference Example 4 and the compound (24) synthesized in Reference Example 24 were used to produce the above compound in the same way as Example 1.

Workup

  1. customto produce the above compound in the same way as Example 1

Sources & evidence

ORD record
ord-d49e044d91ba41819787fce94b25dafb
Source dataset
uspto-grants-1998_03
Patent number
US05723475

Linked notes

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