2-chloro-6-[(3-methyloxetan-3-yl)methyl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[(3-methyloxetan-3-yl)methyl]-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl}amino)thiophene-3-carboxamide

HRID 99012

Reaction equation

HRID 99012 reaction equation
[Cl:22][c:23]1[cH:24][cH:25][c:26]2[c:27]([n:28]1)[CH2:29][N:30]([CH2:33][C:34]1([CH3:38])[CH2:35][O:36][CH2:37]1)[C:31]2=[O:32].[NH2:1][c:2]1[s:3][c:4](-[c:10]2[c:11]([F:21])[cH:12][c:13]([C:17]([CH3:18])([CH3:19])[OH:20])[cH:14][c:15]2[F:16])[cH:5][c:6]1[C:7](=[O:8])[NH2:9]>>[NH:1]([c:2]1[s:3][c:4](-[c:10]2[c:11]([F:21])[cH:12][c:13]([C:17]([CH3:18])([CH3:19])[OH:20])[cH:14][c:15]2[F:16])[cH:5][c:6]1[C:7](=[O:8])[NH2:9])[c:23]1[cH:24][cH:25][c:26]2[c:27]([n:28]1)[CH2:29][N:30]([CH2:33][C:34]1([CH3:38])[CH2:35][O:36][CH2:37]1)[C:31]2=[O:32]

Participants

3

Reactant 2

HCID 582166602-chloro-6-[(3-methyloxetan-3-yl)methyl]-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-oneHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 445546325-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-({6-[(3-methyloxetan-3-yl)methyl]-5-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-2-yl}amino)thiophene-3-carboxamide

Sources & evidence

ORD record
ord-89482d295eae42838bd19cab785ff5f3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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