Diethylene Glycol Monoethyl Ether → Amitriptyline

HRID 990585

Reaction equation

HRID 990585 reaction equation
[CH3:1][N:2]([CH2:4][CH2:5][CH:6]=[C:7]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[CH2:15][CH2:14][C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]1=2)[CH3:3].Cl.CCOCCOCCO>>[CH3:1][N:2]([CH2:4][CH2:5][CH:6]=[C:7]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=2[CH2:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]1=2)[CH3:3]

Participants

3

Reactant 2

HCID 8146Diethylene Glycol Monoethyl EtherHCID 11065Amitriptyline Hydrochloride2×

Product 1

HCID 2160Amitriptyline

Procedure

0.750 gm amitriptyline hydrochloride USP, is wetted with 1.5 ml of ethoxy diglycol reagent, and stirred into 75 gm of the base cream prepared as per example 3 and triple milled. A cream-type preparation results which contains amitriptyline hydrochloride @ 10 mg/ml

Workup

  1. customA cream-type preparation
  2. customresults which

Sources & evidence

ORD record
ord-7b0db97616db43d3a0ee7da715f224af
Source dataset
uspto-grants-2002_10
Patent number
US06461600B1

Linked notes

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