Methanol → Tert-butyl 4-hydroxy-2-methylpiperidine-1-carboxylate

Reaction equation

[BH4-:16].[CH3:18][OH:19].[CH3:1][CH:2]1[N:3]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:4][CH2:5][C:6](=[O:8])[CH2:7]1.[Na+:17]>>[CH3:1][CH:2]1[N:3]([C:9](=[O:10])[O:11][C:12]([CH3:13])([CH3:14])[CH3:15])[CH2:4][CH2:5][CH:6]([OH:8])[CH2:7]1

Participants

Reactant 4

HCID 887Methanol

HCID 923Sodium Ion

HCID 28123Borohydride

HCID 12992764tert-Butyl 2-methyl-4-oxopiperidine-1-carboxylate

Product 1

HCID 22181172Tert-butyl 4-hydroxy-2-methylpiperidine-1-carboxylate

Sources & evidence

ORD record: ord-746a2fc9a5cf40ebb785909345c224d9
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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