4-(4-Phenoxyphenyl)piperidine → N-methyl-N-(1-phenylvinyl)-4-(4-phenoxyphenyl)-1-piperidinacetamide

HRID 991

Reaction equation

HRID 991 reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:20][N:21]([C:26]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[CH2:27])[C:22](=[O:25])[CH2:23]Br>>[CH3:20][N:21]([C:26]([C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[CH2:27])[C:22](=[O:25])[CH2:23][N:17]1[CH2:18][CH2:19][CH:14]([C:11]2[CH:12]=[CH:13][C:8]([O:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)=[CH:9][CH:10]=2)[CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 110759844-(4-Phenoxyphenyl)piperidineHCID 19694241N-methyl-N-(1-phenylvinyl)-2-bromoacetamide

Product 1

HCID 19694268N-methyl-N-(1-phenylvinyl)-4-(4-phenoxyphenyl)-1-piperidinacetamide

Procedure

The compound (4) synthesized in Reference Example 4 and the compound (25) synthesized in Reference Example 25 were used to produce the above compound in the same way as Example 1.

Workup

  1. customto produce the above compound in the same way as Example 1

Sources & evidence

ORD record
ord-dfe2b6a956a846edadea6b92fc42ad40
Source dataset
uspto-grants-1998_03
Patent number
US05723475

Linked notes

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