2,2-Diethoxythioacetamide → 4-(3-Methylisoxazol-5-yl)thiazole-2-carbaldehyde

HRID 992208Notes

Reaction equation

HRID 992208 reaction equation
C(O[CH:4]([O:8]CC)[C:5]([NH2:7])=[S:6])C.Br[CH2:12][C:13]([C:15]1[O:19][N:18]=[C:17]([CH3:20])[CH:16]=1)=O>C(O)C>[CH3:20][C:17]1[CH:16]=[C:15]([C:13]2[N:7]=[C:5]([CH:4]=[O:8])[S:6][CH:12]=2)[O:19][N:18]=1

Participants

4

Reactant 2

HCID 27947342,2-DiethoxythioacetamideHCID 148146892-Bromo-1-(3-methylisoxazol-5-yl)ethanone

Product 1

HCID 184115504-(3-Methylisoxazol-5-yl)thiazole-2-carbaldehyde

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of diethoxythioacetamide (6.65 g; 0.04077 mol) and 2-bromo-1-(3-methylisoxazol-5-yl)ethanone (10 g; 0.04077 mol), prepared as described in the above step, in absolute ethanol (31.3 ml) was kept overnight at room temperature and then refluxed for 30 minutes.

Workup

  1. temperaturerefluxed for 30 minutes

Sources & evidence

ORD record
ord-6518dabbb5744facbae7e3e3e5784d65
Source dataset
uspto-grants-2002_10
Patent number
US06468979B1

Reaction notes

Loading…