Adamantane-1-sulfinyl Chloride → (S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)-1-adamantanesulfinamide

HRID 992335

Reaction equation

HRID 992335 reaction equation
[C:1]12([S:11](Cl)=[O:12])[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[NH2:14][C@H:15]1[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:16]1>>[C:22]1([CH2:21][CH2:20][N:17]2[CH2:18][CH2:19][CH:15]([NH:14][S@:11]([C:1]34[CH2:10][CH:5]5[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]5)[CH2:2]3)[CH2:8]4)=[O:12])[CH2:16]2)[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1

Participants

3

Reactant 2

HCID 4737333Adamantane-1-sulfinyl ChlorideHCID 10774056(3S)-1-(2-Phenylethyl)-3-pyrrolidinamine

Product 1

HCID 70172045(S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)-1-adamantanesulfinamide

Procedure

1-Adamantanesulfinyl chloride and (S)-3-amino-1-(2-phenylethyl)pyrrolidine were reacted under the same conditions as in Example 53 to give (S)-N-(1-(2-phenylethyl)pyrrolidin-3-yl)-1-adamantanesulfinamide.

Sources & evidence

ORD record
ord-6a8c467211484f968e7c3809e41d3fbd
Source dataset
uspto-grants-2002_10
Patent number
US06468998B1

Linked notes

Loading…