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Thymogen

HCID 100094
ノート反応
基本情報概要名称と識別子物性化学と産業関連反応化合物ノート
部分構造検索類似構造を探す

基本情報

CAS
122933-59-9
標準SMILES
N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O
InChIKey
LLEUXCDZPQOJMY-AAEUAGOBSA-N
分子式
C16H19N3O5
平均分子量
333.34 g/mol
単同位体質量
333.13247072

概要

Glu-Trp is a dipeptide composed of L-glutamic acid and L-tryptophan joined by a peptide linkage. It has a role as a metabolite, an antineoplastic agent, an immunomodulator and an angiogenesis modulating agent. It is functionally related to a L-glutamic acid and a L-tryptophan.

名称と識別子

優先名称
Thymogen
IUPAC
(4S)-4-amino-5-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid
英語名
thymogen
分子式
C16H19N3O5
分子量
333.33916

名称と別名

Oglufanide38101-59-6ThymogenGlutamyltryptophanalpha-Glu-TrpL-Tryptophan, L-alpha-glutamyl-L-alpha-Glu-L-Trpoglufanida4RHY598T5UNSC-334073DTXSID10924324NSC334073
名称をさらに表示
GenowhiteAids095357Aids-095357Anti-spot peptide DipeptideAnti-spot peptide Dipeptide powder(4S)-4-[N-((1S)-1-Carboxy-2-indol-3-ylethyl)carbamoyl]-4-aminobutanoic acid
oglufanidumRefChem:167983DTXCID401353167H-Glu-Trp-OHGlu-trpL-glutamyl-L-tryptophanOglufanide [INN]Timogen

データベース識別子

CAS
122933-59-9、38101-59-6
PubChem CID
100094
DTXSID
DTXSID10924324
ChEMBL
CHEMBL2111029
ChEBI
CHEBI:73512
UNII
4RHY598T5U
Nikkaji
J895.715K

物性

構造計算による物性

XLogP
-2.7
極性表面積
146 Ų
水素結合供与体数
5
水素結合受容体数
6
回転可能結合数
8
重原子数
24
形式電荷
0
複雑度
484

実験および物理化学的性質

DrugsPharmaceuticals -> Listed in ZINC15
LogP-2.24
Physical DescriptionSolid

物理化学的性質

InChI
InChI=1/C16H19N3O5/c17-11(5-6-14(20)21)15(22)19-13(16(23)24)7-9-8-18-12-4-2-1-3-10(9)12/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23,24)/t11-,13-/s3
InChIKey
LLEUXCDZPQOJMY-PZILLZCRNA-N
SMILES
C(O)(=O)CC[C@H](N)C(N[C@H](C(O)=O)CC1C2=C(NC=1)C=CC=C2)=O |&1:5,9,r|

化学と産業

薬理情報

PharmacodynamicsOglufanide regulates the body's innate immune response to defeat invading germs and cancer cells. It may control or reverse the suppression of the immune system which the hepatitis virus uses to defeat our normally healthy defenses.
MeSH Pharmacological Classification · 4 件

Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.

Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.

Agents counteracting or neutralizing the action of POISONS.

Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.

応用分野 · 1 件

使用H-Glu-Trp-OH, has show to have potential antiangiogenic and immunomodulating activities. It inhibits vascular endothelial growth factor (VEGF), which may inhibit angiogenesis. This agent has also been reported to stimulate the immune response to hepatitic C virus and intracellular bacterial infections.

サプライヤー32 社

深圳市迈思立生物科技有限公司17549219037 17549219037 · [email protected]

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