N-Succinimidyl 3-(2-pyridyldithio)propionate (HCID 100682)

概要

heterobifunctional reagent

名称と識別子

優先名称: N-Succinimidyl 3-(2-pyridyldithio)propionate
IUPAC: (2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate
現地名: 3-(2-ピリジルジチオ)プロパン酸2,5-ジオキソ-1-ピロリジニル
英語名: SPDP
分子式: C12H12N2O4S2
分子量: 312.36

名称と別名

SPDP68181-17-9N-Succinimidyl 3-(2-pyridyldithio)propionate2OHG8V08NLNSC-3444851-(1-Oxo-3-(2-pyridyldithio)propoxy)pyrrolidine-2,5-dione2,5-Pyrrolidinedione, 1-(1-oxo-3-(2-pyridinyldithio)propoxy)-DTXSID60218366N-SUCCINIMIDYL 3-[2-PYRIDYLDITHIO]PROPIONATESIPDTPRefChem:164199DTXCID80140857

名称をさらに表示

3-[(2-ピリジル)ジチオ]プロパン酸スクシンイミジル3-[(2-ピリジル)ジチオ]プロピオン酸スクシンイミジル3-(2-ピリジニルジチオ)プロピオン酸スクシンイミジル3-(2-ピリジルジチオ)プロパン酸2,5-ジオキソ-1-ピロリジニル3-(2-ピリジルジチオ)プロピオン酸スクシンイミジル3-[(2-ピリジニル)ジチオ]プロパン酸2,5-ジオキソピロリジン-1-イル3-[(2-ピリジル)ジチオ]プロパン酸2,5-ジオキソピロリジン-1-イル3-(2-ピリジニルジチオ)プロピオン酸2,5-ジオキソ-1-ピロリジニル3-(2-ピリジルジチオ)プロピオン酸2,5-ジオキソピロリジノ3-(2-ピリジルジチオ)プロピオン酸2,5-ジオキソ-1-ピロリジニル3-(2-ピリジニルジチオ)プロパン酸2,5-ジオキソピロリジン-1-イルN-[3-(2-ピリジルジチオ)プロピオニルオキシ]スクシンイミド3-(2-ピリジルジチオ)プロピオン酸2,5-ジオキソピロリジン-1-イル1-[1-オキソ-3-(2-ピリジニルジチオ)プロピルオキシ]-2,5-ピロリジンジオン3-(2-ピリジルジチオ)プロパン酸2,5-ジオキソピロリジノ3-[(2-ピリジニル)ジチオ]プロピオン酸スクシンイミジル3-[(2-ピリジニル)ジチオ]プロパン酸2,5-ジオキソ-1-ピロリジニル3-[(2-ピリジル)ジチオ]プロパン酸2,5-ジオキソ-1-ピロリジニル3-(2-ピリジニルジチオ)プロパン酸2,5-ジオキソ-1-ピロリジニルN-スクシンイミジル3-(2-ピリジルジチオ)プロピオナートSUCCINIMIDYL 3-(2-PYRIDYLDITHIO)PROPIONATE2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfaneyl)propanoatePDPH,SPDPSPDP (SPDP Crosslinker)3-(2-PYRIDYLDITHIO)-PROPIONIC ACID-OSU3-(Pyridin-2-yldisulfanyl)-propionic acid-OS

N-succinilimidyl 3-(2-pyridylthio)propionate269-034-33-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide esterSPDP NHS ester2,5-dioxopyrrolidin-1-yl 3-(pyridin-2-yldisulfanyl)propanoateSPDP Crosslinker3-(2-Pyridyldithio)propionic Acid N-Succinimidyl EsterMFCD00009636

データベース識別子

CAS: 68181-17-9
PubChem CID: 100682
DTXSID: DTXSID60218366
UNII: 2OHG8V08NL
EC Number: 269-034-3
Nikkaji: J317.385B

物性

構造計算による物性

XLogP: 0.7
極性表面積: 127 Å²
水素結合供与体数: 0
水素結合受容体数: 7
回転可能結合数: 7
重原子数: 20
形式電荷: 0
複雑度: 376

物理化学的性質

融点: 84 · 84-86 °C(lit.)
沸点: 465.9 · 465.9±55.0 °C(Predicted)
比重(密度): 1.48 · 1.48±0.1 g/cm3(Predicted)
貯蔵温度: -20 °C · -20°C
溶解性: 50 mg/mL · アセトン: 50 mg/mL
外見: 粉
酸解離定数(Pka): 1.76 · 1.76±0.19(Predicted)
色: 白色～淡黄色
BRN: 1548137 · 1548137
安定性: 吸湿性、湿気に敏感
InChI: InChI=1S/C12H12N2O4S2/c15-10-4-5-11(16)14(10)18-12(17)6-8-19-20-9-3-1-2-7-13-9/h1-3,7H,4-6,8H2
InChIKey: JWDFQMWEFLOOED-UHFFFAOYSA-N
SMILES: C(ON1C(=O)CCC1=O)(=O)CCSSC1=NC=CC=C1
CAS データベース: 68181 · 68181-17-9(CAS DataBase Reference)

化学的性質

化学的特性White Solid

安全と法規制

GHS分類

GHS Classification · 4 件

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 42 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory Information2,5-Pyrrolidinedione, 1-1-oxo-3-(2-pyridinyldithio)propoxy-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Hazard Classes and CategoriesSkin Irrit. 2 (100%)

安全データ

F: 1-10
wgk: 3
hs_code: 29333990
risk_code: 36/37/38
hazard_code: Xi
safety_code: 26-36
ストレージクラス: 11 - Combustible Solids

化学と産業

薬理情報

MeSH Pharmacological Classification · 1 件

Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.

応用分野 · 2 件

使用3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.It has been used for antibody conjugation and as a protein cross-linker.

一般的な説明3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is a heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thiol-disulfide exchange buffered at pH 8.0 (7.5-8.5). Alternately, this reagent may be used as a protected thiolating reagent following initial coupling and reduction of linker. It incorporates four atom linker.