フェロセンカルボン酸

説明Ferrocenecarboxylic acid is a metal-organic compound characterized by connecting two ferrocene molecules through a carboxy ligand. Notably, ferrocene is a stable yet highly reactive metal-organic compound that has been extensively researched due to its potential applications in catalysis, materials science, and medicine. It serves as a catalyst in catalysis, facilitating the synthesis of diverse compounds through polymerization, oxidation, and reduction reactions. In materials science, it acts as a fundamental molecular building block for synthesizing polymers and nanomaterials. Although the precise mechanism of action of Ferrocenecarboxylic acid remains fully elucidated, it is believed that the carboxy ligand binds to the ferrocene molecules, forming a stable complex. This complex, in turn, engages with other molecules, including proteins, to facilitate various reactions[1-2].

使用Ferrocenecarboxylic acid (FCA) is a multifunctional organic reagent with applications in the following areas:(1) As a synthetic precursor: synthesising amino-MIL-53(Al) through the adsorption of ferrocene and FCA. Amino-MIL-53(Al) is an amino-functionalised derivative of the metal-organic framework MIL-53(Al).(2) As a chemical additive: Employed in preparing electrode materials and for the electrocatalytic oxidation of NADH.(3) Based on Fca, ferrocenecarboxylic acid-capped pillar[5]arene (FACP5) was synthesised as a guest molecule. This interacts with the host molecule, a galactose derivative (G), to form a supramolecular vesicle system suitable for targeted drug delivery.(4) Fca serves as the key substance generating electrical signals in electrochemical sensors for prostate-specific antigen (PSA) detection. This sensor is suitable for the early clinical diagnosis of prostate cancer.

純化方法It crystallises as yellow crystals from pet ether (m 225-230odec), CHCl3 (m 208.5odec), toluene/pet ether (m 195-205odec), or aqueous ethanol. [Matsue et al. J Am Chem Soc 107 3411 1985.] The acid chloride m 49o crystallises from pentane, and has max at 458nm [Lau & Hart J Org Chem 24 280 1959]. The methyl ester crystallises from aqueous MeOH with m 70-71o. The anhydride has m 143-145o when recrystallised from pet ether [Acton & Silverstein J Org Chem 24 1487 1959]. The amide has m 168-170o when crystallised from CHCl3/Et2O or m 167-169o when crystallised from *C6H6/MeOH. [Arimoto & Haven J Am Chem Soc 77 6295 1955, Benkeser et al. J Am Chem Soc 76 4025 1954.] [Beilstein 16 IV 1807.]