D-manno-2-ヘプツロース

解説D-manno-2-heptulose．C7H14O7(210.18)．アボカドPersea gratissimaやアルファルファMedicago sativaから得られる．"水中では99％ 以上がα-ピラノース形となる．融点151～152 ℃．[α]D＋29.7°(水)．[CAS 3615-44-9]森北出版「化学辞典（第2版）

説明D-Glucose is phosphorylated by glucokinase and three tissue-specific hexokinases to produce glucose-6-phosphate in humans. D-Mannoheptulose is a heptose that inhibits glucokinases and hexokinases from diverse organisms through competition with D-glucose (Ki = 0.25 mM). It blocks glucose oxidation and glucose-mediated insulin release from pancreatic islet cells. D-Mannoheptulose prevents the conversion of glucose to glucose-6-phosphate that can mediate the activation of the carbohydrate response element binding protein. By blocking glucose phosphorylation, D-mannoheptulose causes transient hyperglycemia in dogs when given at 1 g/kg but not at 8 mg/kg, although postprandial energy expenditure is increased at the lower dose.