ベンゾヒドロキサム酸

Benzohydroxamic acid

HCID 10313CAS 32685-16-8

基本情報

標準SMILES
O=C(NO)c1ccccc1
InChIKey
VDEUYMSGMPQMIK-UHFFFAOYSA-N
分子式
C7H7NO2
平均分子量
137.14 g/mol
単同位体質量
137.04767847

名称と識別子

優先名称
Benzohydroxamic acid
IUPAC
N-hydroxybenzamide
現地名
ベンゾヒドロキサム酸
英語名
Benzohydroxamic acid
分子式
C7H7NO2
分子量
137.14

名称と別名

N-HydroxybenzamideBENZOHYDROXAMIC ACID495-18-1Benzhydroxamic acidBenzamide, N-hydroxy-Phenylhydroxamic acidBenzoylhydroxamic acidHydroxylamine, N-benzoyl-DTXSID7025421K8YW73872DNSC-147248DTXCID305421
名称をさらに表示
ベンゾヒドロキサム酸N-ベンゾイルヒドロキシルアミンフェニルヒドロキサム酸ベンズヒドロキシム酸ベンゼンホルムヒドロキサム酸ベンゼンカルボヒドロキサム酸N-ヒドロキシベンゼンカルボアミドN-ヒドロキシベンズアミドベンゾヒドロキシム酸ベンズヒドロキサム酸ベンゾヒドロキサム酸, 99%N-BENZOYLHYDROXYLAMINEBHAMNSC 3136NSC 147248n-hydroxy-benzamidBenzohydroxamsαureBENZOHYROXAMICACID
RefChem:163535207-797-6N-Hydroxy-benzamideBenzohydroxamateBenzohyroxamatebenzenecarbohydroxamic acid122231-61-2MFCD00002109

データベース識別子

CAS
32685-16-8、495-18-1
PubChem CID
10313
DTXSID
DTXSID7025421
ChEMBL
CHEMBL16300
UNII
K8YW73872D
EC Number
207-797-6
Nikkaji
J1.560A

物性

構造計算による物性

XLogP
0.3
極性表面積
49.3 Ų
水素結合供与体数
2
水素結合受容体数
2
回転可能結合数
1
重原子数
10

実験および物理化学的性質

LogP0.26
Solubility5 to 10 mg/mL at 74.7 °F (NTP, 1992)
Boiling PointExplodes (NTP, 1992)
Melting Point · 2 件

259 to 266 °F (NTP, 1992)

128

Physical DescriptionRhombic crystals or light beige solid. (NTP, 1992)

物理化学的性質

融点
126 · 126-130 °C(lit.)
沸点
251.96 °C · 251.96°C (rough estimate)
比重(密度)
1.2528 · 1.2528 (rough estimate)
屈折率
1.503 · 1.5030 (estimate)
貯蔵温度
2 · 2-8°C
溶解性
アルコールに可溶。エーテルにわずかに溶ける。ベンゼンに不溶。

化学的性質

化学的特性Crystalline Solid

安全と法規制

GHS分類

GHS Classification · 5 件

Warning

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation];H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H335 (97%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation];H341 (97%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]

P203, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 33 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Regulatory Information · 3 件

Chemical: Benzamide, N-hydroxy-

Status: No longer Valid Update: 18-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/24948

Benzamide, N-hydroxy-: Does not have an individual approval but may be used under an appropriate group standard

Fire HazardsFlash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)
Health HazardsACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of nitrogen oxides. (NTP, 1992)
Reactive GroupAlcohols and Polyols;Amides and Imides
Reactivity Profile · 1 件

N-HYDROXYBENZAMIDE is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Air and Water ReactionsSlightly soluble in water.

安全と保護具

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)
First Aid · 1 件

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.;SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.;INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.;INGESTION: DO NOT INDUCE VOMITING. If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the chemical and IMMEDIATELY call a hospital or poison control center. Be prepared to transport the victim to a hospital if advised by a physician. If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body. DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital. (NTP, 1992)

Nonfire Spill Response · 1 件

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.;STORAGE PRECAUTIONS: You should store this material in a refrigerator. (NTP, 1992)

Personal Protective Equipment (PPE) · 1 件

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

法規制情報

Regulatory Information · 3 件

Chemical: Benzamide, N-hydroxy-

Status: No longer Valid Update: 18-05-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/24948

Benzamide, N-hydroxy-: Does not have an individual approval but may be used under an appropriate group standard

安全データ

wgk
3
tsca
TSCA listed
rtecs
DF9650000
毒性
LD orl-rat: >500 mg/kg NCNSA6 5,26,53
hs_code
29280090
risk_code
68-40-20/21/22

化学と産業

用途と製造

General Manufacturing InformationBenzamide, N-hydroxy-: ACTIVE
応用分野 · 2 件

使用Benzhydroxamic acid is used as precursor in the synthesis of novel mono-anionic and di-anionic hydroxamato complexes by reacting with BiPh3 and Bi(O(t)Bu)3, which has anti-bacterial activity against helicobacter pylori. It is used in the photometric determination of trace amounts of vanadium in alloy steels by making mixed-ligand vanadium chelates with ammonium thiocyanate. It is also involved in the palladium catalyzed synthesis of benzisoxazolones.

一般的な説明Rhombic crystals or light beige solid.

調製方法 · 1 件

製造方法To a rapidly stirred suspension of 19.6 gm (0.35 mole) of powdered anhydrous potassium hydroxide in 120 ml of pyridine, maintained at 0-5°C, is a added a solution of 13.9 gm (0.2 mole) of hydroxylamine hy­drochloride in 100 ml of pyridine. While maintaining the reaction temperature at 0-5°C, 15 gm (0.1 mole) of ethyl benzoate is added. Vigorous stirring is continued at room tempera­ture for 6 hr. Then the solids are filtered off. The solids are washed with cold water to remove inorganic coproducts. The remainder, recrystallized from aqueous ethanol, represents a 94% yield of potassium benzohy­droxamate. This salt is triturated with cold 0.01 TV hydrochloric acid. From this mixture, by the usual procedures, 12.5 gm (91% overall) of benzohydrox­amic acid is isolated, m.p. 131°C (from aqueous alcohol).

サプライヤー50 社

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
湖北永阔科技有限公司027-59223108 15972152991 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Shandong chuangyingchemical Co., Ltd.18853181302 · [email protected]

関連反応

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