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ビタミンB6

Vitamin B6

HCID 104817
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基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
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基本情報

CAS
8059-24-3
標準SMILES
Cc1ncc(COP(=O)([O-])[O-])c(C)c1O
InChIKey
RBCOYOYDYNXAFA-UHFFFAOYSA-L
分子式
C8H10NO5P-2
平均分子量
231.14 g/mol

概要

Vitamin B6 is a group of water-soluble vitamins essential for metabolism and normal physiological functions. B6 vitamins, including pyridoxine, pyridoxal, and pyridoxamine, are converted in vivo to pyridoxal phosphate, a cofactor necessary for the synthesis of amino acids, neurotransmitters, and sphingolipids. More than 100 enzymes involved in protein metabolism require vitamin B6 as a cofactor. Vitamin B6 is essential to red blood cell, nervous system, and immune systems functions and helps maintain normal blood glucose levels. Vitamin B6 is found in a wide variety of foods including cereals, beans, meat, poultry, fish, and some fruits and vegetables. (NCI04)

名称と識別子

優先名称
Vitamin B6
IUPAC
(5-hydroxy-4,6-dimethyl-3-pyridinyl)methyl phosphate
現地名
ビタミンB6
英語名
Vitamin B6
分子式
C10H16N2O3S
分子量
244.31

名称と別名

8059-24-3Vitamin B 6DTXSID501015372RefChem:902002VIT B6CHEBI:27306232-503-8Vitamin B-6Vitamin B6(5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphateEINECS 232-503-8AKOS015891944
名称をさらに表示
ビタミンB6BIOTINBIOEPIDERM(+)-BIOTINCOENZYME RPiridoxin HCLRONACARE(TM) BIOTIN PLUSBIOS HFACTOR SBIOTINUM
FP09822BIOTIN, IMMOBILIZED ON DEXTRAN-LYSINENS00020888

データベース識別子

CAS
8059-24-3
PubChem CID
104817
EC Number
232-503-8

物性

構造計算による物性

XLogP
-0.9
極性表面積
106 Ų
水素結合供与体数
1
水素結合受容体数
6
回転可能結合数
2
重原子数
15
形式電荷
-2
複雑度
244

実験および物理化学的性質

Chemical ClassesBiological Agents -> Vitamins and Derivatives
Dietary IngredientsVitamin B6

物理化学的性質

融点
231 · 231-233 °C(lit.)
貯蔵温度
2 · 2-8°C
溶解性
2 O: · H2O: 0.2 mg/mL 1N NaOH の添加により溶解度が増加しました。
外見
粉
化粧品成分の機能
帯電防止スキンコンディショニングヘアコンディショニング
InChI
InChI=1S/C8H12NO5P/c1-5-7(4-14-15(11,12)13)3-9-6(2)8(5)10/h3,10H,4H2,1-2H3,(H2,11,12,13)/p-2
InChIKey
RBCOYOYDYNXAFA-UHFFFAOYSA-L
SMILES
C1(C)=NC=C(COP([O-])([O-])=O)C(C)=C1O
CAS データベース
8059 · 8059-24-3(CAS DataBase Reference)

安全と法規制

安全情報は参考情報です。供給元の安全データシート(SDS)、適用法令、専門家による評価に代わるものではありません。

危険有害性情報

Regulatory Information · 3 件

Chemical: Vitamin B6

Regulation (EC) No 1831/2003 (amended)

Vitamin B6: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Hazards SummarySee Pyridoxine hydrochloride.

安全データ

F
8
wgk
1
rtecs
XJ9088200
safety_code
24/25

化学と産業

薬理情報

MeSH Pharmacological ClassificationA group of water-soluble vitamins, some of which are COENZYMES.

用途と製造

Uses · 2 件

VITAMIN B 6 refers to several PICOLINES (especially PYRIDOXINE; PYRIDOXAL; & PYRIDOXAMINE) that are efficiently converted by the body to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, and aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into PYRIDOXAMINE phosphate. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990). Most of vitamin B6 is eventually degraded to PYRIDOXIC ACID and excreted in the urine. [ChemIDplus] Pyridoxine hydrochloride (a form of vitamin B6) is used as a nutritional additive in animal feeds and considered safe for all species; [ExPub: EFSA - FEEDAP]

Farming (Feed Additives) [Category: Industry]

Household ProductsInformation on 1 consumer products that contain Vitamin B6 (Vitamin H) in the following categories is provided:
応用分野 · 3 件

解説ビタミンB6,ビタミンビーろく,ピリドキシン,ピリドキサル,ピリドキサミンが含まれる。ピリドキシンは水溶性で蛋白質代謝に関連が深く,これが欠乏すると,蛋白質から炭水化物,脂肪への転換が押えられる。米ぬか,胚芽,酵母,肝臓に多く含まれる。ビタミン B6 欠乏症では,ペラグラ様皮膚炎,脂漏性皮膚炎,食欲不振,吐き気,口唇炎,B6 反応性鉄芽球性貧血などが起る。1日 10~50mgを内服または注射すると,症状は消失する。水溶性ビタミンのひとつ。たんぱく質の代謝に不可欠な補酵素。皮膚炎を予防する物質として発見されたビタミン。魚類、肉類、鶏卵、豆類などに多く含まれる。大脳や神経の刺激伝達物質を生成し、脳機能を維持する働きをもつほか、赤血球中のヘム合成に関わり血液をサラサラに維持、皮膚や粘膜の抵抗力の向上、免疫力強化、貧血症の予防・改善、動脈硬化症の予防などさまざまな作用をもつ。

説明Vitamin B6 (vitB6), or pyridoxine, is an important compound for general cellular metabolism. Since its discovery in 1934 by Gyrgy and colleagues, it has been implicated as a co-factor in more than 140 biochemical reactions in the cell. Although most vitB6 co-catalyzed reactions are related to amino acid biosynthesis and catabolism, vitB6 also contributes to fatty acid biosynthesis, breakdown of certain storage compounds in animals and plants, as well as in the biosynthesis of plant hormones, neurotransmitters, and organelle-specific compounds such as chlorophyll. In addition, vitamin B6 can quench reactive oxygen species (ROS). Because of its role in ROS scavenging and chlorophyll synthesis, vitamin B6 benefits photosynthesis and is discussed as a possible factor in alleviating abiotic and biotic stress. Vitamin B6 (pyridoxal 5′-phosphate) participates in the process of synthesizing dopamine, epinephrine, norepinephrine, serotonin and GABA. It has also been found to be an antioxidant.

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化合物ノート

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このページの内容基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート

使用Vitamin B6 comprises a group of six water-soluble compounds, including pyridoxal, pyridoxamine, pyridoxine, and their 5′-phosphates. It functions as a versatile coenzyme participating in over 100 biochemical reactions and is generally considered to have negligible toxicity due to its ready metabolism and excretion[1][2][3]. Vitamin B6 serves as a cofactor for approximately 160 reactions, including glycogen breakdown, amino acid transformations, and the synthesis of neurotransmitters such as GABA, dopamine, norepinephrine, and serotonin. Therapeutic administration is used to treat vitamin B6 deficiency (typically around 50 mg/day orally), prevent peripheral neuropathy induced by isoniazid, and manage nausea and vomiting during pregnancy[1][2][3][4].

補足説明

定義本品は、ビタミンB6であり、次の化学式で表される。