4-O-β-D-ガラクトピラノシル-α-D-グルコピラノース·水和物

alpha-Lactose monohydrate

HCID 104938
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基本情報

CAS
5989-81-1
標準SMILES
O.OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
InChIKey
WSVLPVUVIUVCRA-KPKNDVKVSA-N
分子式
C12H24O12
平均分子量
360.31 g/mol
単同位体質量
360.1267762

名称と識別子

優先名称
alpha-Lactose monohydrate
IUPAC
(2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol;hydrate
現地名
4-O-β-D-ガラクトピラノシル-α-D-グルコピラノース·水和物
英語名
Alpha-D-Lactose monohydrate
分子式
C12H24O12
分子量
360.31

名称と別名

5989-81-1alpha-Lactose monohydrateDTXSID1052828alpha-D-Glucopyranose, 4-O-beta-D-galactopyranosyl-, monohydrateRefChem:1076517DTXCID90820517611-913-4Lactose monohydratealpha-D-Lactose monohydrateD-Lactose monohydrate64044-51-5Respitose
名称をさらに表示
4-O-β-D-ガラクトピラノシル-α-D-グルコピラノース·水和物α-乳糖·水和物α-ラクトース·水和物α-ラクトース·一水和物ラクトース一水和物(乳糖)Α-D-ラクトース一水和物ラクトース一水和物, A-Α-ラクトース 一水和物α-ラクトース・水和物4-O-β-D-ガラクトピラノシル-α-D-グルコピラノース・水和物α-ラクトース・一水和物α-Lactoseα-Lactose monohydrateα-D-Lactose monohydrateMILK SUGARALPHA-D-LACTOSEPharmatose 150MLACTOSE MONOHYDRATE (ALPHA-FORM)A-LACTOSE
alpha-lactose hydrateLactose monohydrate [NF](2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-[(2R,3S,4R,5R,6S)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol;hydrateEWQ57Q8I5Xa-D-Glucopyranose, 4-O-b-D-galactopyranosyl-, monohydrateInhalac 120 (contains b anomer)d-(+)-lactose monohydrateLactose monohydrate (NF)

データベース識別子

CAS
5989-81-1、64044-51-5、66857-12-3
PubChem CID
104938
DTXSID
DTXSID1052828
ChEBI
CHEBI:189432
UNII
EWQ57Q8I5X
EC Number
611-913-4

物性

構造計算による物性

極性表面積
191 Ų
水素結合供与体数
9
水素結合受容体数
12
回転可能結合数
4
重原子数
24

実験および物理化学的性質

Physical DescriptionSolid; [Merck Index]

物理化学的性質

融点
219 °C · 219 °C
沸点
412.35 °C · 412.35°C (rough estimate)
比旋光度
20 · [α]D20+52.2～+52.8°
比重(密度)
1 · 1,53 g/cm3
屈折率
1.648 · 1.6480 (estimate)
貯蔵温度
Inert atmosphere,Room Temperature

化学的性質

化学的特性White powder

安全と法規制

GHS分類

GHS Classification · 3 件

This chemical does not meet GHS hazard criteria for 100% (63 of 63) of all reports.

Not Classified；Reported as not meeting GHS hazard criteria by 63 of 63 companies. For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 63 reports by companies from 2 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 63 of 63 reports by companies.；There are 0 notifications provided by 0 of 63 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Regulatory Information · 4 件

Chemical: .alpha.-D-Glucopyranose, 4-O-.beta.-D-galactopyranosyl-, monohydrate

Chemical: D-Glucose, 4-O-.beta.-D-galactopyranosyl-, monohydrate

Lactose monohydrate: Does not have an individual approval but may be used under an appropriate group standard

Lactose monohydrate: Does not have an individual approval but may be used under an appropriate group standard

Other Safety Information · 2 件

IMAP assessments - D-Glucose, 4-O-.beta.-D-galactopyranosyl-, monohydrate: Human health tier I assessment

IMAP assessments - .alpha.-D-Glucopyranose, 4-O-.beta.-D-galactopyranosyl-, monohydrate: Human health tier I assessment；Evaluation - Chemicals that are unlikely to require further regulation to manage risks to environment

Hazards SummaryThe standard milk sugar and lactose of pharmacy; [Merck Index] May cause irritation; [Sigma-Aldrich MSDS] See Lactose.
Hazard Classes and CategoriesNot Classified

法規制情報

Regulatory Information · 4 件

Chemical: .alpha.-D-Glucopyranose, 4-O-.beta.-D-galactopyranosyl-, monohydrate

Chemical: D-Glucose, 4-O-.beta.-D-galactopyranosyl-, monohydrate

Lactose monohydrate: Does not have an individual approval but may be used under an appropriate group standard

Lactose monohydrate: Does not have an individual approval but may be used under an appropriate group standard

安全データ

wgk
3
tsca
Yes
hs_code
17021100
risk_code
40-36/37/38
hazard_code
Xi
safety_code
24/25-36-26

化学と産業

用途と製造

Uses · 1 件

Found in the milk of mammals; Used as a nutrient, in baking mixtures, as pharmaceutic aid (tablet and capsule excipient and diluent), for lactic acid fermentation in ensilage and foods, in culture media, and as chromatographic adsorbent in analytical chemistry; [Merck Index]

Household ProductsInformation on 2 consumer products that contain alpha-Lactose monohydrate in the following categories is provided:；• Personal Care
応用分野 · 3 件

用途糖類研究用。医薬品原料。

用途細菌培養基剤、医薬原料(賦形剤）。

使用alpha-D-Lactose monohydrate is used as a carrier and stabiliser of aromas, pharmaceutical products, Food industry.

調製方法 · 1 件

A suspension of a-lactose monohydrate crystals in a lactose solution is atomized and dried in a spray drier. Approximately 10–20% of the total amount of lactose is in solution and the remaining 80–90% is present in the crystalline form. The spray-drying process predominantly produces spherical particles. The compactibility of the material and its flow characteristics are a function of the primary particle size of the lactose monohydrate and the amount of amorphous lactose.

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補足説明 · 1 件

定義A sugar that occurs in many plants. It is extracted commercially from sugar cane and sugar beet. Sucrose is a disaccharide formed from a glucose unit and a fructose unit. It is hydrolyzed to a mixture of fructose and glucose by the enzyme invertase. Since this mixture has a different optical rotation (levorotatory) than the original sucrose, the mixture is called invert sugar.

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