よう化プロピジウム

Propidium Iodide

HCID 104981

基本情報

CAS
25535-16-4
標準SMILES
CC[N+](C)(CC)CCC[n+]1c(-c2ccccc2)c2cc(N)ccc2c2ccc(N)cc21.[I-].[I-]
InChIKey
XJMOSONTPMZWPB-UHFFFAOYSA-M
分子式
C27H34I2N4
平均分子量
668.4 g/mol
単同位体質量
668.08729

名称と識別子

優先名称
Propidium Iodide
IUPAC
3-(3,8-diamino-6-phenylphenanthridin-5-ium-5-yl)propyl-diethyl-methylazanium diiodide
現地名
よう化プロピジウム
英語名
Propidium iodide
分子式
C27H34IN4+
分子量
541.5

名称と別名

propidium iodide25535-16-4Propidium diiodideCHEBI:51240TP416O228T3,8-Diamino-5-(3-(diethylmethylammonio)propyl)-6-phenylphenanthridinium diiodideDTXSID208940843,8-Diamino-5-[3-(diethylmethylammonio)propyl]-6-phenylphenanthridinium diiodidePhenanthridinium, 3,8-diamino-5-(3-(diethylmethylammonio)propyl)-6-phenyl-, diiodideNSC-169541Diiodide, PropidiumIodide, Propidium
名称をさらに表示
3,8-ジアミノ-5-[3-(ジエチルメチルアミニオ)プロピル]-6-フェニルフェナントリジン-5-イウム·ヨージドプロピジウムヨージドプロピジウム·ヨージドよう化プロピジウム3,8-ジアミノ-5-{3-[ジエチル(メチル)アンモニオ]プロパン-1-イル}-6-フェニルフェナントリジン-5-イウム=ジヨージドプロピジウムヨージド, 1.0MG/1ML SOLUTION INよう化プロピジウム1MG/ML水溶液よう化プロピジウム *1.0MG/ML水溶液*PI(ヨウ化プロピジウム)溶液ヨウ化プロピジウム 溶液3,8-ジアミノ-5-[3-(N,N-ジエチル-N-メチルアミニオ)プロピル]-6-フェニルフェナントリジン-5-イウム・ジヨージド5-[3-(メチルジエチルアミニオ)プロピル]-3,8-ジアミノ-6-フェニルベンゾ[c]キノリン-5-イウム・2ヨージドプロピディウムヨージド3,8-ジアミノ-5-[3-(ジエチルメチルアンモニオ)プロピル]-6-フェニルフェナントリジン-5-イウム・ジヨージドPropidium iodide solution3,8-DIAMINO-5-(3-DIETHYLAMINOPROPYL)-6-PHENYLPHENANTHRIDINIUM IODIDE METHIODIDEPI (Red)Nsc169541C27H34IN4PI solution-Cellstain-PiPI(Powder form)
RefChem:176408DTXCID101324125247-081-0Propidiumiodide3,8-Diamino-5-(3-(diethyl(methyl)ammonio)propyl)-6-phenylphenanthridin-5-ium iodidePropidium (Iodide)MFCD000119213-(3,8-diamino-6-phenylphenanthridin-5-ium-5-yl)propyl-diethyl-methylazanium diiodide

データベース識別子

CAS
25535-16-4
PubChem CID
104981
DTXSID
DTXSID20894084
ChEBI
CHEBI:51240
UNII
TP416O228T
EC Number
247-081-0

物性

構造計算による物性

極性表面積
55.9 Ų
水素結合供与体数
2
水素結合受容体数
4
回転可能結合数
7
重原子数
33

実験および物理化学的性質

Physical DescriptionDark red solid; [Sigma-Aldrich MSDS]

物理化学的性質

融点
220 · 220-225 °C (dec.) (lit.)
比重(密度)
1.5072 · 1.5072 (estimate)
貯蔵温度
2 · 2-8°C
溶解性
混ぜにくい。
外見
フレークパウダー
色
暗赤色
化学的性質 · 1 件

化学的特性Propidium iodide is a dark red to reddish-brown liquid that is soluble in a variety of organic solvents. It is light-sensitive and may decompose upon prolonged exposure to light, leading to the formation of iodine. For optimal stability, it should be stored in a cool, dark place under an inert atmosphere.

安全と法規制

GHS分類

GHS Classification · 5 件

Warning

H315 (98.8%): Causes skin irritation [Warning Skin corrosion/irritation];H319 (98.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H335 (98.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation];H341 (26.1%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]

P203, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 165 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Regulatory InformationPhenanthridinium, 3,8-diamino-5-3-(diethylmethylammonio)propyl-6-phenyl-, diiodide: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummarySubcutaneous LD50 (mouse) = 16 mg/kg; [RTECS] A skin and strong eye irritant; [Sigma-Aldrich MSDS] See Homidium bromide. See Iodine for the TLV of Iodides.
Hazard Classes and CategoriesSkin Irrit. 2 (98.8%);Eye Irrit. 2 (98.8%);STOT SE 3 (98.8%);Muta. 2 (26.1%)

法規制情報

Regulatory InformationPhenanthridinium, 3,8-diamino-5-3-(diethylmethylammonio)propyl-6-phenyl-, diiodide: Does not have an individual approval but may be used under an appropriate group standard

安全データ

F
3-8-10-23
wgk
3
rtecs
SF7949600
hs_code
29339900
risk_code
36/37/38-68-67-48/20/22-40-36/38-22-20-63
hazard_code
Xi,Xn

化学と産業

薬理情報

MeSH Pharmacological Classification · 3 件

Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)

Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA.

Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS.

用途と製造

Uses · 1 件

Quaternary ammonium analog of ethidium; an intercalating dye with a specific affinity to certain forms of DNA and, used as diiodide, to separate them in density gradients; also forms fluorescent complexes with cholinesterase which it inhibits. [ChemIDplus]

応用分野 · 2 件

使用Propidium Iodide is a phenanthridine compound, a class of compounds with reported activity against several species of trypanosomes. Propidium iodide may be used in flow cytometry to evaluate cell viab ility when used with other dyes that stain viable cells or cells that are early in the apoptosis process.

一般的な説明Extinction coefficient(493 nm): 5900 M -1cm-1;(287 nm): 55,700 M -1cm-1;

調製方法

純化方法It crystallises as red crystals from H2O containing a little KI. It fluoresces strongly with nucleic acids. [Watkins J Chem Soc 3064 1952, Beilstein 22 III/IV 5519.] TOXIC.

サプライヤー100 社

北京华美互利生物化工010-56205725 · [email protected]
郑州阿尔法化工有限公司+86-18530059196 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]

関連反応

1 件

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