基本情報
- CAS
25535-16-4- 標準SMILES
CC[N+](C)(CC)CCC[n+]1c(-c2ccccc2)c2cc(N)ccc2c2ccc(N)cc21.[I-].[I-]- InChIKey
XJMOSONTPMZWPB-UHFFFAOYSA-M- 分子式
- C27H34I2N4
- 平均分子量
- 668.4 g/mol
- 単同位体質量
- 668.08729
名称と識別子
- 優先名称
- Propidium Iodide
- IUPAC
- 3-(3,8-diamino-6-phenylphenanthridin-5-ium-5-yl)propyl-diethyl-methylazanium diiodide
- 現地名
- よう化プロピジウム
- 英語名
- Propidium iodide
- 分子式
- C27H34IN4+
- 分子量
- 541.5
名称と別名
名称をさらに表示
データベース識別子
- CAS
25535-16-4- PubChem CID
- 104981
- DTXSID
DTXSID20894084- ChEBI
CHEBI:51240- UNII
- TP416O228T
- EC Number
- 247-081-0
物性
構造計算による物性
- 極性表面積
- 55.9 Ų
- 水素結合供与体数
- 2
- 水素結合受容体数
- 4
- 回転可能結合数
- 7
- 重原子数
- 33
- 形式電荷
- 0
- 複雑度
- 555
実験および物理化学的性質
物理化学的性質
- 融点
- 220 · 220-225 °C (dec.) (lit.)
- 比重(密度)
- 1.5072 · 1.5072 (estimate)
- 貯蔵温度
- 2 · 2-8°C
- 溶解性
- 混ぜにくい。
- 外見
- フレークパウダー
- 色
- 暗赤色
- 水溶解度
- 1 mg/mlで水に溶ける · 1mg/mlで水に溶ける
- BRN
- 3843838 · 3843838
- 主な用途
- アポトーシス検出;細胞周期解析
- InChIKey
- ISKCJFFZOPXOFC-UHFFFAOYSA-N
- SMILES
- C([N+]1=C2C=C(N)C=CC2=C2C=CC(N)=CC2=C1C1C=CC=CC=1)CC[N+](C)(CC)CC.[I-]
- CAS データベース
- 25535 · 25535-16-4(CAS DataBase Reference)
化学的性質
化学的特性Propidium iodide is a dark red to reddish-brown liquid that is soluble in a variety of organic solvents. It is light-sensitive and may decompose upon prolonged exposure to light, leading to the formation of iodine. For optimal stability, it should be stored in a cool, dark place under an inert atmosphere.
安全と法規制
GHS分類
GHS Classification
Warning
H315 (98.8%): Causes skin irritation [Warning Skin corrosion/irritation];H319 (98.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation];H335 (98.8%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation];H341 (26.1%): Suspected of causing genetic defects [Warning Germ cell mutagenicity]
P203, P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P318, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 165 reports by companies from 11 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
危険有害性情報
法規制情報
安全データ
- F
- 3-8-10-23
- wgk
- 3
- rtecs
- SF7949600
- hs_code
- 29339900
- risk_code
- 36/37/38-68-67-48/20/22-40-36/38-22-20-63
- hazard_code
- Xi,Xn
- safety_code
- 26-36-22-36/37
- ストレージクラス
- 12 - Non Combustible Liquids
化学と産業
薬理情報
MeSH Pharmacological Classification
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA.
Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS.
用途と製造
Uses
Quaternary ammonium analog of ethidium; an intercalating dye with a specific affinity to certain forms of DNA and, used as diiodide, to separate them in density gradients; also forms fluorescent complexes with cholinesterase which it inhibits. [ChemIDplus]
応用分野
使用Propidium Iodide is a phenanthridine compound, a class of compounds with reported activity against several species of trypanosomes. Propidium iodide may be used in flow cytometry to evaluate cell viab ility when used with other dyes that stain viable cells or cells that are early in the apoptosis process.
一般的な説明Extinction coefficient(493 nm): 5900 M -1cm-1;(287 nm): 55,700 M -1cm-1;
調製方法
純化方法It crystallises as red crystals from H2O containing a little KI. It fluoresces strongly with nucleic acids. [Watkins J Chem Soc 3064 1952, Beilstein 22 III/IV 5519.] TOXIC.
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