テトラキス(ヒドロキシメチル)ホスホニウム·ヒドロキシド

THE TOXICITY OF THE FLAME RETARDANTS, TRIS(2,3-DIBROMOPROPYL)PHOSPHATE, PYROVATEX CP, & TETRAKIS(HYDROXYMETHYL)PHOSPHONIUM HYDROXIDE (THPOH), WERE STUDIED IN A 30-DAY EXPERIMENT WITH GOLDFISH. AT A CONCN OF 1 PPM, THPOH WAS MORE TOXIC THAN PYROVATEX CP BUT LESS TOXIC THAN TRIS(2,3-DIBROMOPROPYL)PHOSPHATE. ALL FISH EXPOSED TO TRIS(2,3-DIBROMOPROPYL)PHOSPHATE WERE DEAD WITHIN 5 DAYS.

SPOT TESTS SHOWED TETRAMETHYLOLPHOSPHONIUM CHLORIDE TO BE NONMUTAGENIC IN SALMONELLA TYPHIMURIUM STRAINS TA100, TA98, TA1535 & TA1537 WITH & WITHOUT S-9 MIX USING 1,000, 300, 100 & 10 UG/PLATE.

Groups of ten 4 week old F-344/N rats of each sex were gavaged 5 days/week for 13 weeks with 0, 3.75, 7,5, 15, 30 or 60 mg THPC (as 75% aqueous solution) per kg. All males and 5/10 females that received 60 mg/kg died. The final mean body weight of males that received 30 mg/kg was 89% of vehicle controls. The final mean body weight of females that received 60 in mg/kg was 80% of vehicle controls.

Groups of five 6 week old, F 344/N rats of each sex were administered 0, 9.4, 18.8, 37.5, 75 or 150 mg THPC (as a 75% aqueous solution) per: kg body weight in deionized water by gavage 14 days. At the two highest dose levels an increased mortality was observed. At 75 mg/kg the mortality for males was 20%, and at 150 mg/kg all males and females died. The body weight gain of the male animals administered 18.8 and .37.5 mg/kg was decreased, respectively, by 7 and 11%. This effect was also found in the females administered 75 mg/kg (27%). Rats with 150 mg/kg had yellow to tan or mottled red livers. No histopathology was carried out.

For more Non-Human Toxicity Excerpts (Complete) data for TETRAMETHYLOLPHOSPHONIUM HYDROXIDE (11 total), please visit the HSDB record page.

/SRP:/ Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poison A and B/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in respiratory arrest. Positive pressure ventilation techniques with a bag valve mask device may be beneficial. Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start an IV with D5W /SRP: "To keep open", minimal flow rate/. Use lactated Ringer's if signs of hypovolemia are present. Watch for signs of fluid overload. Consider drug therapy for pulmonary edema ... . For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poison A and B/