ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
化工社オープンプロジェクト:[email protected]AIアクセス:llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.7.8
  1. ホーム
  2. /化合物

エコチオパートヨウ化物

Echothiophate Iodide

HCID 10547
ノート反応
基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート
部分構造検索類似構造を探す

基本情報

CAS
513-10-0
標準SMILES
CCOP(=O)(OCC)SCC[N+](C)(C)C.[I-]
InChIKey
OVXQHPWHMXOFRD-UHFFFAOYSA-M
分子式
C9H23INO3PS
平均分子量
383.23 g/mol
単同位体質量
383.0181

概要

Ecothiopate iodide is the iodide salt of ecothiopate. An irreversible acetylcholinesterase inhibitor, it is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inadequate. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor, an antiglaucoma drug and a miotic. It is an iodide salt and a quaternary ammonium salt. It contains an ecothiopate.

名称と識別子

優先名称
Echothiophate Iodide
IUPAC
2-diethoxyphosphorylsulfanylethyl(trimethyl)azanium iodide
現地名
エコチオパートヨウ化物
英語名
Ecothiopate iodide
分子式
C9H23INO3PS
分子量
383.227051

名称と別名

Echothiophate iodideECOTHIOPATE IODIDE513-10-0EchodideEcothiophate iodideEcothiopati iodidumPhospholine iodideIodure d'ecothiopateIoduro de ecotiopato217-miDiethoxyphosphoryl-thiocholine iodideEchothiophate iodide (USP)
名称をさらに表示
エコチオパート2-[(ジエトキシホスフィニル)チオ]エタンアミニウムヨウ化エコチオパートエコチオパートヨウ化物エコチオパートヨウ化物 (JP17)エコチオファートイオジドヨウ化エコチオファートエコチオファートヨージド2-[(ジエトキシホスフィニル)チオ]-N,N,N-トリメチルエタンアミニウム・ヨージドECHOTHIOPHATEEcothiopate217MIEcostigmineECOTHIOPHATEPHOSPHOLINEIODIDEEchothiopate iodide
2-Diethoxy-phosphinylthioethyl-trimethylammonium iodideBA9QH3P00TEthanaminium, 2-((diethoxyphosphinyl)thio)-N,N,N-trimethyl-, iodideN-(2-(Diethoxyphosphinylthio)ethyl)trimethylammonium iodideO,O-Diethyl S-2-trimethylammonium ethylphosphonothiolate iodideDTXSID1022976S-(2-(N,N,N-Trimethylammonio)ethyl) O,O-diethylphosphorothiolate iodide(2-Mercaptoethyl)trimethylammonium iodide S-ester with O,O-diethyl phosphorothioate

物性

構造計算による物性

極性表面積
60.8 Ų
水素結合供与体数
0
水素結合受容体数
5
回転可能結合数
8
重原子数
16
形式電荷
0
複雑度
208

実験および物理化学的性質

Human Drugs · 3 件

Breast Feeding; Lactation; Cholinesterase Inhibitors; Miotics; Parasympathomimetics

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

物理化学的性質

融点
138 ° · 138° (Tammelin); mp 124-124.5° (Fitch)
貯蔵温度
-20 °C · Store at -20°C
溶解性
DMSO: Slightly Soluble; Methanol: Slightly Soluble; Water: Slightly Soluble
外見
A solid
安定性
Hygroscopic
EPAの化学物質情報
2 · Ethanaminium, 2-[(diethoxyphosphinyl)thio]-N,N,N-trimethyl-, iodide (513-10-0)

安全と法規制

安全情報は参考情報です。供給元の安全データシート(SDS)、適用法令、専門家による評価に代わるものではありません。

毒性情報

Effects During Pregnancy and Lactation◉ Summary of Use during Lactation

安全データ

ridadr
3249
hazard_class
6.1(a)
packing_group
II

化学と産業

薬理情報

MeSH Pharmacological Classification · 3 件

Drugs that inhibit cholinesterases. The neurotransmitter ACETYLCHOLINE is rapidly hydrolyzed, and thereby inactivated, by cholinesterases. When cholinesterases are inhibited, the action of endogenously released acetylcholine at cholinergic synapses is potentiated. Cholinesterase inhibitors are widely used clinically for their potentiation of cholinergic inputs to the gastrointestinal tract and urinary bladder, the eye, and skeletal muscles; they are also used for their effects on the heart and the central nervous system.

Agents causing contraction of the pupil of the eye. Some sources use the term miotics only for the parasympathomimetics but any drug used to induce miosis is included here.

Drugs that mimic the effects of parasympathetic nervous system activity. Included here are drugs that directly stimulate muscarinic receptors and drugs that potentiate cholinergic activity, usually by slowing the breakdown of acetylcholine (CHOLINESTERASE INHIBITORS). Drugs that stimulate both sympathetic and parasympathetic postganglionic neurons (GANGLIONIC STIMULANTS) are not included here.

応用分野 · 2 件

使用Cholinergic (ophthalmic).

使用Echothiophate is a phosphorylthiocholine with pharmacological action analogous to that of isofluorophate; however, spontaneous reduction of phosphorylated enzyme occurs faster after using isofluorophate. It is used in various forms of glaucoma.

上流・下流製品情報

上流原料

ヨードメタンナトリウムクロロりん酸ジエチル

サプライヤー11 社

関連反応

0 件
反応記録を作成

現在のフィルター条件では反応記録がありません。

化合物ノート

読み込み中…

このページの内容基本情報概要名称と識別子物性安全と法規制化学と産業関連反応化合物ノート

データベース識別子

CAS
513-10-0
PubChem CID
10547
DTXSID
DTXSID1022976
ChEMBL
CHEMBL1200367
ChEBI
CHEBI:59849
UNII
BA9QH3P00T
EC Number
208-152-1
安耐吉化学&3A(安徽泽升科技有限公司)
021-58432009 400-005-6266 · [email protected]
銳迪國際科技有限公司18024082417 · [email protected]
Chongqing jooe co., ltd+86-15223382610 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
BOC Sciences16314854226; +8616314854226 · [email protected]
艾吉析科技(上海)有限公司17717235263 17717235263 · [email protected]
TargetMol中国(陶术生物)4008200310 15002144251 · [email protected]
ChemeGen 中国18818260767 · [email protected]
上海一飞生物科技有限公司021-65675885 18964387627 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354 · [email protected]
AFINE CHEMICALS LIMITED+86-571-85134551 +86-18958018566 · [email protected]

補足説明

定義ChEBI: The iodide salt of ecothiopate. An irreversible acetylcholinesterase inhibitor, it is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inadequate.