基本情報
- CAS
522-48-5- 標準SMILES
Cl.c1ccc2c(c1)CCCC2C1=NCCN1- InChIKey
BJORNXNYWNIWEY-UHFFFAOYSA-N- 分子式
- C13H17ClN2
- 平均分子量
- 236.74 g/mol
- 単同位体質量
- 236.1080262
概要
Tetrahydrozoline hydrochloride is the hydrochloride salt of tetryzoline. It is used as a nasal decongestant. It has a role as a sympathomimetic agent, a vasoconstrictor agent and a nasal decongestant. It contains a tetryzoline(1+).
名称と識別子
- 優先名称
- Tetrahydrozoline Hydrochloride
- IUPAC
- 2-(1,2,3,4-tetrahydronaphthalen-1-yl)-4,5-dihydro-1H-imidazole;hydrochloride
- 現地名
- 塩酸テトラヒドロゾリン
- 英語名
- 2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride
- 分子式
- C13H16N2.ClH
- 分子量
- 236.74
名称と別名
Tetrahydrozoline hydrochloride522-48-5Tetrahydrozoline HClTetryzoline hydrochlorideTyzineVasoposTyzanol hydrochlorideRhinoprontDTXSID70453160YZT43HS7DNSC-7573392-(1,2,3,4-Tetrahydro-1-naphthyl)-2-imidazoline hydrochloride
名称をさらに表示
4,5-ジヒドロ-2-[(1,2,3,4-テトラヒドロナフタレン)-1-イル]-1H-イミダゾール·塩酸塩塩酸テトラヒドロゾリンテトラヒドロゾリン·塩酸2-(1,2,3,4-テトラヒドロナフタレン-1-イル)-4,5-ジヒドロ-1H-イミダゾール·塩酸塩塩酸テトリゾリンテトラヒドロゾリン塩酸塩テトラヒドロゾリン 塩酸塩塩酸テトラヒドロゾリン (JAN)TetrahydrozlineTetrahydrozoline hyrdrochlorideTETRAHYDROZOLINEHYDROCHLORIDE,USPTetrahydrozoline·hydrochloric acidTetrahydrozoline Hydrochloride (200 mg)SootheTizine
2-(1,2,3,4-Tetrahydro-1-naphthyl)-2-imidazoline monohydrochloride1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, monohydrochlorideCHEBI:9492DTXCID5025316Redness RelieverT-raojoEquate Eye DropsDg Health Original
物性
構造計算による物性
- 極性表面積
- 24.4 Ų
- 水素結合供与体数
- 2
- 水素結合受容体数
- 1
- 回転可能結合数
- 1
- 重原子数
- 16
- 形式電荷
- 0
- 複雑度
- 259
実験および物理化学的性質
Solubility>35.5 [ug/mL] (The mean of the results at pH 7.4)
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Collision Cross Section145.9 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
物理化学的性質
- 融点
- 248 · 248-251°C
- 貯蔵温度
- Inert atmosphere,Room Temperature
- 溶解性
- 2 O: · H2O: 自由に溶ける
- 外見
- Solid
- 色
- ホワイトからオフホワイト
- 水溶解度
- 2 O: · H2O: freely solublealcohol: freely solublechloroform: very slightly solublediethyl ether: insoluble
- InChI
- InChI=1S/C13H16N2.ClH/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13;/h1-2,4,6,12H,3,5,7-9H2,(H,14,15);1H
- InChIKey
- BJORNXNYWNIWEY-UHFFFAOYSA-N
- SMILES
- C1(CCCC2=CC=CC=C12)C1=NCCN1.Cl
- CAS データベース
- 522 · 522-48-5(CAS DataBase Reference)
- EPAの化学物質情報
- 1 H-Imidazole, · 1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, monohydrochloride (522-48-5)
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
GHS分類
GHS Classification
Warning
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 46 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
危険有害性情報
Other Safety InformationIMAP assessments - 1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, monohydrochloride: Environment tier I assessment
Hazard Classes and CategoriesAcute Tox. 4 (100%)
安全データ
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- NJ4550000
- hs_code
- 2933290000
- risk_code
- 22-36/37/38
- hazard_code
- Xn,Xi
- safety_code
- 26-36
- Hazard Classifications
- Acute Tox. 4 OralEye Irrit. 2Skin Irrit. 2STOT SE 3
- ストレージクラス
- 11 - Combustible Solids
化学と産業
薬理情報
MeSH Pharmacological Classification
Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS.
Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)
用途と製造
General Manufacturing Information1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, hydrochloride (1:1): ACTIVE
応用分野
使用2-Tetralin-1-yl-4,5-dihydro-1H-imidazole hydrochloride is an alpha agonist, causing constriction of conjunctival blood vessels,it is used in over-the-counter eye drops, this compound relieves the redness left by ocular irritants.
上流・下流製品情報
上流原料
サプライヤー100 社
関連反応
0 件
現在のフィルター条件では反応記録がありません。
化合物ノート
読み込み中…