基本情報
- CAS
644-26-8- 標準SMILES
CCC(C)(CN(C)C)OC(=O)c1ccccc1- InChIKey
FDMBBCOBEAVDAO-UHFFFAOYSA-N- 分子式
- C14H21NO2
- 平均分子量
- 235.32 g/mol
- 単同位体質量
- 235.15722891
概要
Stovaine is a benzoate ester.
名称と識別子
- 優先名称
- Amylocaine
- IUPAC
- [1-(dimethylamino)-2-methylbutan-2-yl] benzoate
- 現地名
- アミロカイン
- 英語名
- 1-[(dimethylamino)methyl]-1-methylpropyl benzoate
- 分子式
- C14H21NO2
- 分子量
- 235.32
名称と別名
AmylocaineStovaine644-26-8QRW683O56T1-(DIMETHYLAMINO)-2-METHYL-2-BUTANOL BENZOATEDTXSID6047862(1-((dimethylamino)methyl)-1-methyl-propyl) benzoate[1-[(dimethylamino)methyl]-1-methyl-propyl] benzoateRefChem:557965DTXCID2027838211-411-1Amyleine
名称をさらに表示
1-(ジメチルアミノ)-2-メチル-2-ブタノールベンゾアート安息香酸1-[(ジメチルアミノ)メチル]-1-メチルプロピルストバインアミロカインアミレイン1-(ジメチルアミノ)-2-メチルブタン-2-イル ベンゾアートStovain2-Butanol, 1-(dimethylamino)-2-methyl-, 2-benzoateBenzoic acid 1-[(dimethylamino)methyl]-1-methylpropyl ester
Amylocaine [BAN]1-(Dimethylamino)-2-methylbutan-2-yl benzoate[1-(dimethylamino)-2-methylbutan-2-yl] benzoateEINECS 211-411-1Amylocaine (BAN)1-[(Dimethylamino)methyl]-1-methylpropyl benzoate1-((Dimethylamino)methyl)-1-methylpropyl benzoate2-Butanol, 1-(dimethylamino)-2-methyl-, benzoate
データベース識別子
- CAS
644-26-8- PubChem CID
- 10767
物性
構造計算による物性
- XLogP
- 3
- 極性表面積
- 29.5 Ų
- 水素結合供与体数
- 0
- 水素結合受容体数
- 3
- 回転可能結合数
- 6
- 重原子数
- 17
- 形式電荷
- 0
- 複雑度
- 247
実験および物理化学的性質
Human DrugsPharmaceuticals
物理化学的性質
- 沸点
- 377.72 °C · 377.72°C (rough estimate)
- 比重(密度)
- 1.0247 · 1.0247 (rough estimate)
- 屈折率
- 1.5385 · 1.5385 (estimate)
安全と法規制
安全情報は参考情報です。供給元の安全データシート（SDS）、適用法令、専門家による評価に代わるものではありません。
安全データ
- 毒性
- LDLo ivn-rat: 25 mg/kg PHREA7 12,262,32
化学と産業
薬理情報
Protein BindingA lack of detailed information regarding the specificities of amylocaine relate to a lack of information on its pharmacokinetics at the time of its primary use in the early 1900s.
Pharmacodynamics
Like all other local anesthetics, amylocaine acts as a membrane stabilizing drug that reversibly decreases the rate of depolarization and depolarization of excitable membranes. In this way, the conduction of neuronal signals for certain bodily movements can be blocked. In particular, when administered for spinal anesthesia, the resultant anesthesia can typically extend from the chest to the legs.
Mechanism of Action
In particular, amylocaine, much like other local anesthetics, bind and blockade voltage gated sodium channels located in the excitable membranes of various sensory receptors. Once blocked, the influx of sodium across the channels and membrane is inhibited. Because the influx of sodium is necessary to facilitate neuronal action potentials and signal conduction across sensory receptor membranes, the influx inhibition subsequently prevents the body reactions that would normally result from the neuronal signals.
Biological Half-LifeA lack of detailed information regarding the specificities of amylocaine relate to a lack of information on its pharmacokinetics at the time of its primary use in the early 1900s.
Metabolism/MetabolitesA lack of detailed information regarding the specificities of amylocaine relate to a lack of information on its pharmacokinetics at the time of its primary use in the early 1900s.
Absorption, Distribution and Excretion
A lack of detailed information regarding the specificities of amylocaine relate to a lack of information on its pharmacokinetics at the time of its primary use in the early 1900s.
A lack of detailed information regarding the specificities of amylocaine relate to a lack of information on its pharmacokinetics at the time of its primary use in the early 1900s.
A lack of detailed information regarding the specificities of amylocaine relate to a lack of information on its pharmacokinetics at the time of its primary use in the early 1900s.
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