インドキサカルブ

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

SRP: Local exhaust ventilation should be applied wherever there is an incidence of point source emissions or dispersion of regulated contaminants in the work area. Ventilation control of the contaminant as close to its point of generation is both the most economical and safest method to minimize personnel exposure to airborne contaminants.

SRP: Contaminated protective clothing should be segregated in such a manner so that there is no direct personal contact by personnel who handle, dispose, or clean the clothing. Quality assurance to ascertain the completeness of the cleaning procedures should be implemented before the decontaminated protective clothing is returned for reuse by the workers. Contaminated clothing should not be taken home at end of shift, but should remain at employee's place of work for cleaning.

The protective clothing should be kept in separate places where it cannot be contaminated with toxic chemicals. It should be forbidden to keep this clothing in living quarters. Protective clothing must be washed at least once a week and each time it is contaminated with pesticides. Before washing the clothing should be soaked for several hours in a calcium carbonate solution. /Pesticides/

Smoking, eating, and drinking before washing should be absolutely prohibited when any pesticide ... is being handled or used. /Pesticides/

Tolerances are established for the combined residues of the insecticide indoxacarb, (S)-methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy)phenyl] amino]carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate, and its R-enantimomer, (R)-methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy)phenyl]amino] carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate, in or on the following raw agricultural commodities: apple, 1.0 ppm; apple, wet pomace, 3.0 ppm; brassica, head and stem, subgroup 5A, 5.0 ppm; alfalfa, forage, 10 ppm; alfalfa, hay, 50 ppm; cattle, fat, 1.5 ppm; cattle, meat, 0.05 ppm; cattle, meat byproducts, 0.03 ppm; corn, sweet, forage, 10 ppm; corn, sweet, kernel plus cob with husk removed, 0.02 ppm; corn, sweet, stover, 15 ppm; cotton gin byproducts, 15 ppm; cotton, undelinted seed, 2.0 ppm; goat, fat, 1.5 ppm; goat, meat, 0.05 ppm; goat, meat byproducts, 0.03 ppm; hog, fat, 1.5 ppm; hog, meat, 0.05 ppm; hog, meat byproducts, 0.03 ppm; horse, fat, 1.5 ppm; horse, meat, 0.05 ppm; horse, meat byproducts, 0.03 ppm; lettuce, head, 5.0 ppm; lettuce, leaf, 10 ppm; milk, 0.15 ppm; milk, fat, 4.0 ppm; pear, 0.20 ppm; peanut, 0.01 ppm; peanut, hay, 40 ppm; potato, 0.01 ppm; sheep, fat, 1.5 ppm; sheep, meat, 0.05 ppm; sheep, meat byproducts, 0.03 ppm; soybean, aspirated grain fractions, 45 ppm; soybean, hulls, 4.0 ppm; soybean, seed, 0.80 ppm; and vegetable, fruiting, group 8, 0.50 ppm.

Time-limited tolerances are established for combined residues of indoxacarb, (S)-methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl) [4-(trifluoromethoxy) phenyl]amino] carbonyl] indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate, and its R-enantiomer, (R)-methyl 7-chloro- 2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy) phenyl]amino] carbonyl]indeno[1,2-e] [1,3,4]oxadiazine-4a(3H)-carboxylate, in connection with use of the pesticide under FIFRA section 5 experimental use permit granted by EPA. The tolerances will expire and are revoked on the dates specified: cherry, sweet 1.0 ppm (Expiration/revocation date May 21, 2007); cherry, tart 1.0 ppm (Expiration/revocation date May 21, 2007); and peach 10 ppm (Expiration/revocation date May 15, 2006).

Time-limited tolerances are established for the residues of indoxacarb, (S)-methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy)phenyl] amino]carbonyl]indeno [1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate, and its R-enantiomer, (R)-methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy)phenyl] amino]carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate, in connection with use of the pesticide under section 18 emergency exemptions granted by EPA. The tolerances will expire and are revoked on the dates specified: collards 3.0 ppm (Expiration/revocation date 6/30/06; and cranberry 0.50 ppm (Expiration/revocation date 12/31/07).

Very few case reports of acute indoxacarb ingestion are reported in the literature. Reported treatments commonly involve treatment with methylene blue (A15205) (A15207) (A15206). Severe metabolic acidosis was treated with continuous veno-venous hemofiltration (CVVHF) and bicarbonate (NaHCO3) (A15207).

Acute ingestion of indoxacarb causes methemoglobinemia (A15205). Indoxacarb poisoning has also been associated with acute kidney injury, involving acute renal failure and severe metabolic acidosis (A15207). A case involving rhabdomyolysis, in addition to methemoglobinemia and acute kidney injury, has also been reported (A15206).

LD50 Colinus virginianus (Bobwhite quail) oral 98 mg/kg /DPX-MP062, 3:1 mixture of (S) and (R) isomers/

LC50 Anas platyrhynchos (Mallard duck) dietary >5620 ppm/5 days /DPX-MP062, 3:1 mixture of (S) and (R) isomers/

LC50 Colinus virginianus (Bobwhite quail) dietary 808 ppm/5 days /DPX-MP062, 3:1 mixture of (S) and (R) isomers/

LC50 Daphnia 0.60 mg/L/48 hr /Conditions of bioassay not specified in source examined/ /DPX-MP062, 3:1 mixture of (S) and (R) isomers/

For more Ecotoxicity Values (Complete) data for INDOXACARB (7 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 8,100(SRC), determined from a log Kow of 4.65(2) and a regression-derived equation(3), indicates that indoxacarb is expected to be immobile in soil(SRC). Volatilization of indoxacarb from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 6.6X10-10 atm-cu m/mole(SRC), derived from its vapor pressure, 1.9X10-10 mm Hg(2), and water solubility, 0.20 mg/L(2). Indoxacarb is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(2). Biodegradation data were not available(SRC, 2005).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 8,100(SRC), determined from a log Kow of 4.65(2) and a regression-derived equation(3), indicates that indoxacarb is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 6.6X10-10 atm-cu m/mole(SRC), derived from its vapor pressure, 1.9X10-10 mm Hg(2), and water solubility, 0.20 mg/L(2). According to a classification scheme(4), an estimated BCF of 2,000(SRC), from an estimated log Kow(2) and a regression-derived equation(5), suggests the potential for bioconcentration in aquatic organisms is very high(SRC). Aqueous hydrolysis half-lives measured for indoxacarb were greater than 30 days at pH 5, 38 days at pH 7, and 1 day at pH 9(2). Biodegradation data were not available(SRC, 2005).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), indoxacarb, which has a vapor pressure of 1.9X10-10 mm Hg at 25 °C(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase indoxacarb may be removed from the air by wet and dry deposition(SRC).

It is thought that indoxacarb's aromatic metabolites biotransform to active intermediates that produce methemoglobin (A15207). The mechanism of indoxacarb-induced renal injury and metabolic acidosis in humans remains unclear. (A15207) It has been suggested that acute kidney injury results from indoxacarb-induced circulatory shock (A15206). Rhabdomyolysis may have been induced by methemoglobinemia (A15206).

Human toxicity includes eye irritation, blurred vision, skin sensitization with allergic rashes, alteration in blood cell counts, and/or anemia (A15205). As methemoglobin levels increase, typical symptoms develop. Levels of 20 – 50% will cause respiratory distress, dizziness, headache, and fatigue as in this case. Lethargy and stupor develop at levels around 50% and death may occur around 70%. (A15206)

The Koc of indoxacarb is estimated as 8,100(SRC), using a log Kow of 4.65(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that indoxacarb is expected to be immobile in soil.

An estimated BCF of 2,000 was calculated for indoxacarb(SRC), using an estimated log Kow of 4.65(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is very high(SRC), provided the compound is not altered physically or chemically once released into the environment.

Tolerances are established for the combined residues of the insecticide indoxacarb, (S)-methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy)phenyl] amino]carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate, and its R-enantimomer, (R)-methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy)phenyl]amino] carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate, in or on the following raw agricultural commodities: apple; apple, wet pomace; brassica, head and stem, subgroup 5A; alfalfa, forage; alfalfa, hay; cattle, fat; cattle, meat; cattle, meat byproducts; corn, sweet, forage; corn, sweet, kernel plus cob with husk removed; corn, sweet, stover; cotton gin byproducts; cotton, undelinted seed; goat, fat; goat, meat; goat, meat byproducts; hog, fat; hog, meat; hog, meat byproducts; horse, fat; horse, meat; horse, meat byproducts; lettuce, head; lettuce, leaf; milk; milk, fat; pear; peanut; peanut, hay; potato; sheep, fat; sheep, meat; sheep, meat byproducts; soybean, aspirated grain fractions; soybean, hulls; soybean, seed; and vegetable, fruiting, group 8.

Time-limited tolerances are established for combined residues of indoxacarb, (S)-methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl) [4-(trifluoromethoxy) phenyl]amino] carbonyl] indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate, and its R-enantiomer, (R)-methyl 7-chloro- 2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy) phenyl]amino] carbonyl]indeno[1,2-e] [1,3,4]oxadiazine-4a(3H)-carboxylate, in connection with use of the pesticide under FIFRA section 5 experimental use permit granted by EPA. The tolerances will expire and are revoked on the dates specified: cherry, sweet (Expiration/revocation date May 21, 2007); cherry, tart (Expiration/revocation date May 21, 2007); and peach (Expiration/revocation date May 15, 2006).

Time-limited tolerances are established for the residues of indoxacarb, (S)-methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy)phenyl] amino]carbonyl]indeno [1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate, and its R-enantiomer, (R)-methyl 7-chloro-2,5-dihydro-2-[[(methoxycarbonyl)[4-(trifluoromethoxy)phenyl] amino]carbonyl]indeno[1,2-e][1,3,4]oxadiazine-4a(3H)-carboxylate, in connection with use of the pesticide under section 18 emergency exemptions granted by EPA. The tolerances will expire and are revoked on the dates specified: collards (Expiration/revocation date 6/30/06; and cranberry Expiration/revocation date 12/31/07).

Used as broad spectrum insecticide in cotton, vegetables, and fruit; [HSDB] A new reduced risk pesticide to replace organophosphates; Proposed for use on apples, pears, Brassica, sweet corn, lettuce, and fruiting vegetables to control insects, including the beet armyworm; [Reference #1]

Farming (Pesticides) [Category: Industry]

For indoxacarb (USEPA/OPP Pesticide Code: 067710) ACTIVE products with label matches. /SRP: Registered for use in the U.S. but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses./

Insecticide

Broad spectrum control of lepidoptera and certain other pests in cotton, vegetables, and fruit.

This is a man-made compound that is used as an insecticide.

Dispersible granule; suspension concentrate.

DPX-JW062 is a 1:1 mixture of the (active) (S)- and (inactive) (R)- isomers; DPX-MP062 is a 3:1 mixture of these isomers. The pure (S)- isomer is referred to as DPX-KN128, the (R)- isomer as DPX-KN127.

Trade names: Avaunt, Steward, Avatar, Rumo, Tornado

Insecticides

Environmental transformation -> Pesticides (parent, predecessor)